Evidence map›Paper›PMID 28484984›Full record

ArticleThe journal of physiological sciences : JPS2018

The central clock controls the daily rhythm of Aqp5 expression in salivary glands.

Hitoshi Uchida, Takahiro J Nakamura, Nana N Takasu, Aya Obana-Koshino, Hitomi Ono, Takeshi Todo, Takayoshi Sakai, Wataru Nakamura

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physiological sciences : JPS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Hitoshi UchidaDepartment of Oral-Chrono Physiology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, Nagasaki, 852-8588, Japan.
Takahiro J NakamuraDepartment of Life Sciences, School of Agriculture, Meiji University, Kawasaki, Kanagawa, 214-8571, Japan.
Nana N TakasuDepartment of Oral-Chrono Physiology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, Nagasaki, 852-8588, Japan.
Aya Obana-KoshinoDepartment of Oral-Facial Disorders, Graduate School of Dentistry, Osaka University, Suita, Osaka, 565-0871, Japan.
Hitomi OnoDepartment of Oral-Facial Disorders, Graduate School of Dentistry, Osaka University, Suita, Osaka, 565-0871, Japan.
Takeshi TodoDepartment of Radiation Biology and Medical Genetics, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.
Takayoshi SakaiDepartment of Oral-Facial Disorders, Graduate School of Dentistry, Osaka University, Suita, Osaka, 565-0871, Japan.
Wataru NakamuraDepartment of Oral-Chrono Physiology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, Nagasaki, 852-8588, Japan. wataru_nakamura@nagasaki-u.ac.jp.
Osaka University · JPNagasaki University · JPMeiji University · JP

Funding

Japan Society for the Promotion of Science 26462809Japan Society for the Promotion of Science 26860160Japan Society for the Promotion of Science 26861780
6 · The paper itself

Abstract

Salivary secretion displays day-night variations that are controlled by the circadian clock. The central clock in the suprachiasmatic nucleus (SCN) regulates daily physiological rhythms by prompting peripheral oscillators to adjust to changing environments. Aquaporin 5 (Aqp5) is known to play a key role in salivary secretion, but the association between Aqp5 and the circadian rhythm is poorly understood. The aim of our study was to evaluate whether Aqp5 expression in submandibular glands (SMGs) is driven by the central clock in the SCN or by autonomous oscillations. We observed circadian oscillations in the activity of period circadian protein homolog 2 and luciferase fusion protein (PER2::LUC) in cultured SMGs with periodicity depending on core clock genes. A daily rhythm was detected in the expression profiles of Aqp5 in SMGs in vivo. In cultured SMGs ex vivo, clock genes showed distinct circadian rhythms, whereas Aqp5 expression did not. These data indicate that daily Aqp5 expression in the mouse SMG is driven by the central clock in the SCN.

Indexed as

AnimalsAquaporin 5Circadian ClocksCircadian RhythmMaleMiceMice, TransgenicPeriod Circadian ProteinsSubmandibular GlandSuprachiasmatic NucleusAquaporin 5Per2 protein, mousePeriod Circadian ProteinsAquaporin 5Circadian rhythmPeriod 2Salivary glandSuprachiasmatic nucleus

Identifiers

PMID28484984
PMCPMC10717580
OpenAlexW2613619843

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.