ArticleNeurocritical care2017
Functional MRI for Assessment of the Default Mode Network in Acute Brain Injury.
Article in Neurocritical care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 47 citations in OpenAlex.
- Multimodal prediction of residual consciousness in the intensive care unit: the CONNECT-ME study.Brain : a journal of neurology · 2023Trial
- Early Identification of Recovery Potential After Acute Brain Injury Using Functional Near-Infrared Spectroscopy.Neurocritical care · 2026Article
- Changes in the Default Mode Network and Recovery of Impaired Consciousness in Traumatic Brain Injury: A Case Series.Diagnostics (Basel, Switzerland) · 2026Article
- Neurological Outcome Beyond the ICU in Patients with Severe Acute Brain Injury: A Knowledge gap for ICU Teams.Journal of intensive care medicine · 2026Observational
- Multimodal multicentre investigation of diagnostic and prognostic markers in disorders of consciousness.Brain : a journal of neurology · 2026Article
- Multimodal Artificial Intelligence for Precision Critical Care: A Scoping Review.Health data science · 2026Review
- Do individuals with disorders of consciousness dream and mind wander? Implications for improving diagnosis and understanding patient wellbeing.Neuroscience of consciousness · 2025Article
- Arterial Spin Labeling Magnetic Resonance Imaging for Acute Disorders of Consciousness in the Intensive Care Unit.Neurocritical care · 2024Article
- Neuroimaging in Disorders of Consciousness and Recovery.Physical medicine and rehabilitation clinics of North America · 2024Review
- Predicting neurologic recovery after severe acute brain injury using resting-state networks.Journal of neurology · 2023Article
- Prognosis of consciousness disorders in the intensive care unit.Presse medicale (Paris, France : 1983) · 2023Review
- The temporal dynamics of Large-Scale brain network changes in disorders of consciousness: A Microstate-Based study.CNS neuroscience & therapeutics · 2023Article
- Treatable brain network biomarkers in children in coma using task and resting-state functional MRI: a case series.Frontiers in neurology · 2023Article
- Electrophysiological correlates of thalamocortical function in acute severe traumatic brain injury.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
- Applications of Advanced MRI to Disorders of Consciousness.Seminars in neurology · 2022Review
- Meso-scale network analysis of resting state-fMRI brain network connectivity performs poorly as a prognostic tool in critically ill traumatic brain injury patients.Neuroimage. Reports · 2022Article
- Association of network connectivity via resting state functional MRI with consciousness, mortality, and outcomes in neonatal acute brain injury.NeuroImage. Clinical · 2022Article
- Correcting cardiorespiratory noise in resting-state functional MRI data acquired in critically ill patients.Brain communications · 2022Article
- Proceedings of the First Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness.Neurocritical care · 2021Article
- A Precision Medicine Framework for Classifying Patients with Disorders of Consciousness: Advanced Classification of Consciousness Endotypes (ACCESS).Neurocritical care · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAssessment of the default mode network (DMN) using resting-state functional magnetic resonance imaging (fMRI) may improve assessment of the level of consciousness in chronic brain injury, and therefore, fMRI may also have prognostic value in acute brain injury. However, fMRI is much more challenging in critically ill patients because of cardiovascular vulnerability, intravenous sedation, and artificial ventilation.
methodsUsing resting-state fMRI, we investigated the DMN in a convenience sample of patients with acute brain injury admitted to the intensive care unit. The DMN was classified dichotomously into "normal" and "grossly abnormal." Clinical outcome was assessed at 3 months.
resultsSeven patients with acute brain injury (4 females; median age 37 years [range 14-71 years]; 1 traumatic brain injury [TBI]; 6 non-TBI) were investigated by fMRI a median of 15 days after injury (range 5-25 days). Neurological presentation included 2 coma, 1 vegetative state/unresponsive wakefulness syndrome (VS/UWS), 3 minimal conscious state (MCS) minus, and 1 MCS plus. Clinical outcomes at 3 months included 1 death, 1 VS/UWS, 1 MCS plus, and 4 conscious states (CS; 1 modified Rankin Scale 0; 2 mRS 4; 1 mRS 5). Normal DMNs were seen in 4 out of 7 patients (1 MCS plus, 3 CS at follow-up).
conclusionsIt is feasible to assess the DMN by resting-state fMRI in patients with acute brain injury already in the very early period of intensive care unit admission. Although preliminary data, all patients with a preserved DMN regained consciousness levels at follow-up compatible with MCS+ or better.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.