ArticleAnalytical and bioanalytical chemistry2017
Improving repeatability of capillary electrophoresis-a critical comparison of ten different capillary inner surfaces and three criteria of peak identification.
Article in Analytical and bioanalytical chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Capillary Electrophoresis-Mass Spectrometry at Trial by Metabo-Ring: Effective Electrophoretic Mobility for Reproducible and Robust Compound Annotation.Analytical chemistry · 2020Trial
- Article
- Capillary Electrophoresis Optimization for Metabolite Separation inInternational journal of molecular sciences · 2025Article
- A Software Tool for Rapid and Automated Preprocessing of Large-Scale Serum Metabolomic Data by Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry.Analytical chemistry · 2025Article
- [Progress of highly reproducible capillary electrophoresis].Se pu = Chinese journal of chromatography · 2024Article
- Analysis of DNA Origami Nanostructures Using Capillary Electrophoresis.Analytical chemistry · 2023Article
- Hydrogen-Deuterium-Exchange-Based Mass Distribution Shifts in High-Resolution Cyclic Ion Mobility Separations.Journal of the American Society for Mass Spectrometry · 2023Article
- The Use of Antibiotics as Chiral Selectors in Capillary Electrophoresis: A Review.Molecules (Basel, Switzerland) · 2022Review
- A Review of Optical Fibre Ethanol Sensors: Current State and Future Prospects.Sensors (Basel, Switzerland) · 2022Review
- Examining the Effects of Netropsin on the Curvature of DNA A-Tracts Using Electrophoresis.Molecules (Basel, Switzerland) · 2021Article
- Analytical Platforms for Mass Spectrometry-Based Metabolomics of Polar and Ionizable Metabolites.Advances in experimental medicine and biology · 2021Article
- Maltitol: Analytical Determination Methods, Applications in the Food Industry, Metabolism and Health Impacts.International journal of environmental research and public health · 2020Review
- SLIM Ultrahigh Resolution Ion Mobility Spectrometry Separations of Isotopologues and Isotopomers Reveal Mobility Shifts due to Mass Distribution Changes.Analytical chemistry · 2019Article
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Authors and funding
5 authors.
Funding
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Abstract
A poor repeatability of migration times caused by the fluctuations of electroosmotic flow (EOF) is an inherent weakness of capillary electrophoresis. Most researchers endeavor to prevent this problem using relative migration times or various capillary coatings which are expensive and not easy in comparison. Herein, we present an original approach to this problem: we apply a model sample designed to induce significant EOF instability, in order to critically compare ten capillary types with different physicochemical characteristics. Moreover, we accompany capillary modification with the evaluation of various criteria of peak identification: migration time, migration times ratio, and electrophoretic mobility. Our results show a great effectiveness of a dynamic coating in the stabilization of migration times, with the average RSD(%) value reduced from 3.5% (bare silica capillary) down to 0.5%. The good outcomes were also obtained for the surfactant-modified silica and amine capillaries. For the capillaries exhibiting significant instability of EOF, electrophoretic mobility turned out to be a more universal and reliable criterion of peak identification than relative migration time. It can be explained by an intrinsic dependency of migration times ratio on EOF change, which should always be considered during the selection of an internal standard.
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