ArticleeNeuro
Hippocampus-Dependent Goal Localization by Head-Fixed Mice in Virtual Reality.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 45 citations in OpenAlex.
- Coordinated Representational Drift Across the Mouse Cortex.bioRxiv : the preprint server for biology · 2026Article
- Hippocampus shapes entorhinal cortical output through a direct feedback circuit.Nature neuroscience · 2025Article
- Adult zebrafish can learn Morris water maze-like tasks in a two-dimensional virtual reality system.Cell reports methods · 2024Article
- Mice Recognise Mice in Neighbouring Rearing Cages and Change Their Social Behaviour.Behavioural neurology · 2024Article
- Non-consummatory behavior signals predict aversion-resistant alcohol drinking in head-fixed mice.Neuropharmacology · 2024Article
- Adult-born granule cells facilitate remapping of spatial and non-spatial representations in the dentate gyrus.Neuron · 2023Article
- Assessing cognitive decline in the aging brain: lessons from rodent and human studies.npj aging · 2023Review
- Non-Consummatory Behavior Signals Predict Aversion-Resistant Alcohol Drinking in Head-Fixed Mice.bioRxiv : the preprint server for biology · 2023Article
- Refinements to rodent head fixation and fluid/food control for neuroscience.Journal of neuroscience methods · 2022Review
- Perspectives on Cognitive Phenotypes and Models of Vascular Disease.Arteriosclerosis, thrombosis, and vascular biology · 2022Review
- Effect of simultaneous testing of two mice in the tail suspension test and forced swim test.Scientific reports · 2022Article
- Brain region and gene dosage-differential transcriptomic changes inFrontiers in molecular neuroscience · 2022Article
- Article
- Goal-directed interaction of stimulus and task demand in the parahippocampal region.Hippocampus · 2021Review
- Modality-Specific Impairment of Hippocampal CA1 Neurons of Alzheimer's Disease Model Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Multiple coordinated cellular dynamics mediate CA1 map plasticity.Hippocampus · 2021Article
- Gene Dosage- and Age-Dependent Differential Transcriptomic Changes in the Prefrontal Cortex ofFrontiers in molecular neuroscience · 2021Article
- Distinct Mechanisms of Over-Representation of Landmarks and Rewards in the Hippocampus.Cell reports · 2020Article
- Two Functionally Distinct Serotonergic Projections into Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Conformity-like behaviour in mice observing the freezing of other mice: a model of empathy.BMC neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The demonstration of the ability of rodents to navigate in virtual reality (VR) has made it an important behavioral paradigm for studying spatially modulated neuronal activity in these animals. However, their behavior in such simulated environments remains poorly understood. Here, we show that encoding and retrieval of goal location memory in mice head-fixed in VR depends on the postsynaptic scaffolding protein Shank2 and the dorsal hippocampus. In our newly developed virtual cued goal location task, a head-fixed mouse moves from one end of a virtual linear track to seek rewards given at a target location along the track. The mouse needs to visually recognize the target location and stay there for a short period of time to receive the reward. Transient pharmacological blockade of fast glutamatergic synaptic transmission in the dorsal hippocampus dramatically and reversibly impaired performance of this task. Encoding and updating of virtual cued goal location memory was impaired in mice deficient in the postsynaptic scaffolding protein Shank2, a mouse model of autism that exhibits impaired spatial learning in a real environment. These results highlight the crucial roles of the dorsal hippocampus and postsynaptic protein complexes in spatial learning and navigation in VR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.