ArticleRoyal Society open science2017
An agent-based model of anoikis in the colon crypt displays novel emergent behaviour consistent with biological observations.
Article in Royal Society open science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- The Role of Fibroblast-Epithelial Cross-Talk on the Distribution of Distinct Fibroblast Phenotypes in the Intestinal Crypt.Bulletin of mathematical biology · 2026Article
- Exploring the Role of Genetic and Environmental Features in Colorectal Cancer Development: An Agent-Based Approach.Entropy (Basel, Switzerland) · 2024Article
- Article
- Mathematical modelling identifies conditions for maintaining and escaping feedback control in the intestinal epithelium.Scientific reports · 2022Article
- PRIMAGE project: predictive in silico multiscale analytics to support childhood cancer personalised evaluation empowered by imaging biomarkers.European radiology experimental · 2020Observational
- Agent-based modeling of morphogenetic systems: Advantages and challenges.PLoS computational biology · 2019Review
- Chronic TNFα-driven injury delays cell migration to villi in the intestinal epithelium.Journal of the Royal Society, Interface · 2018Article
- Are Tumor Cell Lineages Solely Shaped by Mechanical Forces?Bulletin of mathematical biology · 2017Article
- An agent-based model of anoikis in the colon crypt displays novel emergent behaviour consistent with biological observations.Royal Society open science · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) is a major cause of cancer mortality. Colon crypts are multi-cellular flask-shaped invaginations of the colonic epithelium, with stem cells at their base which support the continual turnover of the epithelium with loss of cells by anoikis from the flat mucosa. Mutations in these stem cells can become embedded in the crypts, a process that is strongly implicated in CRC initiation. We describe a computational model which includes novel features, including an accurate representation of the geometry of the crypt mouth. Model simulations yield previously unseen emergent phenomena, such as localization of cell death to a small region of the crypt mouth which corresponds with that observed
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.