ReviewJournal of animal science and biotechnology2017
Fetal and neonatal programming of postnatal growth and feed efficiency in swine.
Review in Journal of animal science and biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 105 citations in OpenAlex.
- Association Between Maternal Protein Intake and the Risk of Adverse Pregnancy Outcomes.Nutrients · 2026Article
- Weighted Single-Step Genomic Evaluation of Body Structural Traits for Early Selection of Growth Performance in Thai Swamp Buffalo.Animals : an open access journal from MDPI · 2026Article
- Current Understanding of Bovine Ketosis: From Molecular Basis to Farm-Level Management.Animals : an open access journal from MDPI · 2025Review
- Metabolomic analysis of the endometrium of Large White and Meishan pigs reveals differences in biological processes during late gestation.BMC genomics · 2025Article
- Cultural and Traditional Dietary Practices Among African Pregnant Women: A Scoping Review.Cureus · 2025Review
- Maternal 25-Hydroxycholecalciferol Supplementation Dynamically Altered Milk Fatty Acid and Amino Acid Profiles and Improves Sow Performance.Animals : an open access journal from MDPI · 2025Article
- Effects of the Litter of Origin and Rearing Litter Size on the Reproductive Potential of Replacement Gilts.Animals : an open access journal from MDPI · 2025Article
- Evaluation of organ and skeletal physiological characteristics for improved classification of growth-restricted newborn piglets.Scientific reports · 2025Article
- Impact of parturition induction, farrowing environment and birth weight class on endocrine and metabolic plasma parameters related to piglet vitality.BMC veterinary research · 2025Article
- Maternal Overnutrition in Beef Cattle: Effects on Fetal Programming, Metabolic Health, and Postnatal Outcomes.Biology · 2025Review
- Chemical coding of piglets small intestine neurons after prenatal exposure to β-hydroxy-β-methylbutyrate.Journal of veterinary research · 2025Article
- Placental Protein Citrullination Signatures Are Modified in Early- and Late-Onset Fetal Growth Restriction.International journal of molecular sciences · 2025Article
- Effect of Low- and High-Sulfur-Containing Amino Acid Inclusion in Diets Fed to Primiparous Sows in Late Gestation on Pre-Partum Nitrogen Retention and Offspring Pre- and Post-Weaning Growth Performance.Animals : an open access journal from MDPI · 2024Article
- Impact of Precision Feeding During Gestation on the Performance of Sows over Three Cycles.Animals : an open access journal from MDPI · 2024Article
- Dietary 25-Hydroxycholecalciferol Supplementation from Day 85 of Gestation to Farrowing Enhances Performance, Antioxidant Capacity, and Immunoglobulins of Sows and Newborn Piglets.Animals : an open access journal from MDPI · 2024Article
- The maternal lifestyle in pregnancy: Implications for foetal skeletal muscle development.Journal of cachexia, sarcopenia and muscle · 2024Review
- Supplementing Monosodium Glutamate in Sow Diets Enhances Reproductive Performance in Lactating Sows and Improves the Growth of Suckling Piglets.Animals : an open access journal from MDPI · 2024Article
- Effects of Low and High Maternal Protein Intake on Fetal Skeletal Muscle miRNAome in Sheep.Animals : an open access journal from MDPI · 2024Article
- Chemical Composition of Newborn Piglets with Different Weights at Birth in Sows with a High Reproductive Performance.Animals : an open access journal from MDPI · 2024Article
- Gestational Caloric Restriction Alters Adipose Tissue Methylome and Offspring's Metabolic Profile in a Swine Model.International journal of molecular sciences · 2024Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maternal undernutrition or overnutrition during pregnancy alters organ structure, impairs prenatal and neonatal growth and development, and reduces feed efficiency for lean tissue gains in pigs. These adverse effects may be carried over to the next generation or beyond. This phenomenon of the transgenerational impacts is known as fetal programming, which is mediated by stable and heritable alterations of gene expression through covalent modifications of DNA and histones without changes in DNA sequences (namely, epigenetics). The mechanisms responsible for the epigenetic regulation of protein expression and functions include chromatin remodeling; DNA methylation (occurring at the 5´-position of cytosine residues within CpG dinucleotides); and histone modifications (acetylation, methylation, phosphorylation, and ubiquitination). Like maternal malnutrition, undernutrition during the neonatal period also reduces growth performance and feed efficiency (weight gain:feed intake; also known as weight-gain efficiency) in postweaning pigs by 5-10%, thereby increasing the days necessary to reach the market body-weight. Supplementing functional amino acids (e.g., arginine and glutamine) and vitamins (e.g., folate) play a key role in activating the mammalian target of rapamycin signaling and regulating the provision of methyl donors for DNA and protein methylation. Therefore, these nutrients are beneficial for the dietary treatment of metabolic disorders in offspring with intrauterine growth restriction or neonatal malnutrition. The mechanism-based strategies hold great promise for the improvement of the efficiency of pork production and the sustainability of the global swine industry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.