Evidence map›Paper›PMID 28484422›Full record

ArticleFrontiers in neurology2017

Cortical and Striatal Reward Processing in Parkinson's Disease Psychosis.

Sara Garofalo, Azucena Justicia, Gonzalo Arrondo, Anna O Ermakova, Pranathi Ramachandra, Carina Tudor-Sfetea, Trevor W Robbins, Roger A Barker, Paul C Fletcher, Graham K Murray

Open access · goldAbstract read
In one paragraph

Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Sara GarofaloDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Azucena JusticiaDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Gonzalo ArrondoDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Anna O ErmakovaDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Pranathi RamachandraCambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK.
Carina Tudor-SfeteaDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Trevor W RobbinsBehavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
Roger A BarkerDepartment of Clinical Neuroscience, University of Cambridge, Cambridge, UK.
Paul C FletcherDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Graham K MurrayDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
University of Cambridge · GBCambridgeshire and Peterborough NHS Foundation Trust · GBCambridge University Hospitals NHS Foundation Trust · GB

Funding

Medical Research Council G0001354Medical Research Council G0701911Medical Research Council G1000183Wellcome Trust
6 · The paper itself

Abstract

Psychotic symptoms frequently occur in Parkinson's disease (PD), but their pathophysiology is poorly understood. According to the National Institute of Health RDoc programme, the pathophysiological basis of neuropsychiatric symptoms may be better understood in terms of dysfunction of underlying domains of neurocognition in a trans-diagnostic fashion. Abnormal cortico-striatal reward processing has been proposed as a key domain contributing to the pathogenesis of psychotic symptoms in schizophrenia. This theory has received empirical support in the study of schizophrenia spectrum disorders and preclinical models of psychosis, but has not been tested in the psychosis associated with PD. We, therefore, investigated brain responses associated with reward expectation and prediction error signaling during reinforcement learning in PD-associated psychosis. An instrumental learning task with monetary gains and losses was conducted during an fMRI study in PD patients with (

Indexed as

fMRIposterior cingulate cortexprediction errorreinforcement learningventral striatum

Identifiers

PMID28484422
PMCPMC5402044
OpenAlexW2608322377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.