ArticleFrontiers in aging neuroscience2017
Functional Connectivity Disruption in Subjective Cognitive Decline and Mild Cognitive Impairment: A Common Pattern of Alterations.
Article in Frontiers in aging neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03978052 (Prevention of Cognitive Decline in ApoE4 Carriers With Subjective Cognitive Decline After EGCG and a Multimodal Intervention), which is not on this map. Cited by 74 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevention of Cognitive Decline in ApoE4 Carriers With Subjective Cognitive Decline After EGCG and a Multimodal Intervention
Who cites it
74 citing papers in PubMed, 1 synthesis or guideline pooled it, 145 citations in OpenAlex.
- Brain network disintegration as a final common pathway for delirium: a systematic review and qualitative meta-analysis.NeuroImage. Clinical · 2019Pooled it
- Elevated CSF GAP-43 is associated with reduced cerebral glucose metabolism and cognitive impairment in individuals with mild cognitive impairment.Brain imaging and behavior · 2026Article
- Plasma p-tau231 and NfL differently associate with functional connectivity patterns in cognitively unimpaired individuals.GeroScience · 2026Article
- Dynamics of brain connectivity across the Alzheimer's disease spectrum through magnetoencephalography.Scientific reports · 2026Article
- Fast Interneuron Dysfunction in Laminar Neural Mass Model Reproduces Alzheimer's Oscillatory Biomarkers.Human brain mapping · 2026Article
- EEG biomarkers for Alzheimer's disease: A novel automated pipeline for detecting and monitoring disease progression.Journal of Alzheimer's disease : JAD · 2025Article
- Potential Risk to Brain Health after Surgical Interventions: Biomarkers to Predict the Occurrence of Cognitive Decline.Aging and disease · 2025Review
- Dynamic functional connectivity is modulated by the amount of p-Tau231 in blood in cognitively intact participants.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- A Shift Toward Supercritical Brain Dynamics Predicts Alzheimer's Disease Progression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Decoding in the Fourth Dimension: Classification of Temporal Patterns and Their Generalization Across Locations.Human brain mapping · 2025Article
- Effects of Alzheimer's disease plasma marker levels on multilayer centrality in healthy individuals.Alzheimer's research & therapy · 2025Article
- High-power transient 12-30 Hz beta event features as early biomarkers of Alzheimer's disease conversion: An MEG study.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Individual alpha frequency tACS reduces static functional connectivity across the default mode network.Frontiers in human neuroscience · 2025Article
- Electrophysiology of gliomas: current science, implications, and opportunities.Frontiers in oncology · 2025Review
- Hyperbolic Graph Embedding of MEG Brain Networks to Study Brain Alterations in Individuals With Subjective Cognitive Decline.IEEE journal of biomedical and health informatics · 2024Article
- Toward a more comprehensive understanding of network centrality disruption in amnestic mild cognitive impairment: a MEG multilayer approach.Alzheimer's research & therapy · 2024Article
- Machine Learning Classification of Patients with Amnestic Mild Cognitive Impairment and Non-Amnestic Mild Cognitive Impairment from Written Picture Description Tasks.Brain sciences · 2024Article
- Longitudinal changes in the functional connectivity of individuals at risk of Alzheimer's disease.GeroScience · 2024Article
- Dynamic functional connectivity is modulated by the amount of p-Tau231 in blood in cognitively intact participants.bioRxiv : the preprint server for biology · 2024Article
- Is EEG Entropy a Useful Measure for Alzheimer's Disease?Actas espanolas de psiquiatria · 2024Review
14 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional connectivity (FC) alterations represent a key feature in Alzheimer's Disease (AD) and provide a useful tool to characterize and predict the course of the disease. Those alterations have been also described in Mild Cognitive Impairment (MCI), a prodromal stage of AD. There is a growing interest in detecting AD pathology in the brain in the very early stages of the disorder. Subjective Cognitive Decline (SCD) could represent a preclinical asymptomatic stage of AD but very little is known about this population. In the present work we assessed whether FC disruptions are already present in this stage, and if they share any spatial distribution properties with MCI alterations (a condition known to be highly related to AD). To this end, we measured electromagnetic spontaneous activity with MEG in 39 healthy control elders, 41 elders with SCD and 51 MCI patients. The results showed FC alterations in both SCD and MCI compared to the healthy control group. Interestingly, both groups exhibited a very similar spatial pattern of altered links: a hyper-synchronized anterior network and a posterior network characterized by a decrease in FC. This decrease was more pronounced in the MCI group. These results highlight that elders with SCD present FC alterations. More importantly, those disruptions affected AD typically related areas and showed great overlap with the alterations exhibited by MCI patients. These results support the consideration of SCD as a preclinical stage of AD and may indicate that FC alterations appear very early in the course of the disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.