ArticleFrontiers in neural circuits2017
Mechanistic Resolution Required to Mediate Operant Learned Behaviors: Insights from Neuronal Ensemble-Specific Inactivation.
Article in Frontiers in neural circuits, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Refinement of Nucleus Accumbens Neuronal Dynamics during Cocaine Self-Administration Training.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Brain-wide mapping reveals temporal and sexually dimorphic opioid actions.Communications biology · 2026Article
- Recruitment of Neuronal Populations in the Paraventricular Thalamus of Alcohol-Seeking Rats With Withdrawal-Related Learning Experience.Biological psychiatry global open science · 2025Article
- Distinct prelimbic cortex ensembles encode response execution and inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Contingent Amygdala Inputs Trigger Heterosynaptic LTP at Hippocampus-To-Accumbens Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Prelimbic Ensembles Mediate Cocaine Seeking After Behavioral Acquisition and Once Rats Are Well-Trained.Frontiers in behavioral neuroscience · 2022Article
- Inactivation of the infralimbic cortex decreases discriminative stimulus-controlled relapse to cocaine seeking in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Separate vmPFC Ensembles Control Cocaine Self-Administration Versus Extinction in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Sucrose Abstinence and Environmental Enrichment Effects on Mesocorticolimbic DARPP32 in Rats.Scientific reports · 2018Article
- Chasing the addicted engram: identifying functional alterations in Fos-expressing neuronal ensembles that mediate drug-related learned behavior.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Review
- Parvalbumin-Expressing Neurons in the Nucleus Accumbens: A New Player in Amphetamine Sensitization and Reward.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
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3 authors at 3 institutions in 1 country.
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Abstract
Many learned behaviors are directed by complex sets of highly specific stimuli or cues. The neural mechanisms mediating learned associations in these behaviors must be capable of storing complex cue information and distinguishing among different learned associations-we call this general concept "mechanistic resolution". For many years, our understanding of the circuitry of these learned behaviors has been based primarily on inactivation of specific cell types or whole brain areas regardless of which neurons were activated during the cue-specific behaviors. However, activation of all cells or specific cell types in a brain area do not have enough mechanistic resolution to encode or distinguish high-resolution learned associations in these behaviors. Instead, these learned associations are likely encoded within specific patterns of sparsely distributed neurons called neuronal ensembles that are selectively activated by the cues. This review article focuses on studies of neuronal ensembles in operant learned responding to obtain food or drug rewards. These studies suggest that the circuitry of operant learned behaviors may need to be re-examined using ensemble-specific manipulations that have the requisite level of mechanistic resolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.