ArticleScientific reports2017
Measuring nanoscale viscoelastic parameters of cells directly from AFM force-displacement curves.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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Who cites it
86 citing papers in PubMed, 266 citations in OpenAlex.
- Magnetically Driven Biofabrication for Tissue Engineering: From Nanoparticle Design to Mag-ATMP Translation.Advanced healthcare materials · 2026Review
- Hybrid Physics-Informed and Bayesian Modeling of Single-Nanoparticle-Cell Adhesion Kinetics under Cytoskeletal Perturbation.Computational and structural biotechnology journal · 2026Article
- Probing Viscoelasticity of Polymeric Coatings Using Nonlinear Dynamic Atomic Force Microscopy.Small methods · 2026Article
- Comparison of viscoelastic properties of breast cancer and normal cells using AFM, FLIM and ToF-SIMS techniques.Scientific reports · 2025Article
- Tuning Poly(dimethylsiloxane) Hydrophilization and Coating Stability via the Optimization of Polyethylene Glycol Molecular Weight.Polymers · 2025Article
- Atomic force microscope protocols for characterising the elastoviscoplastic biomechanical properties of corneocytes.Communications biology · 2025Article
- At the Pointy End of Mechanobiology: AFM for Transient Biomechanical Analysis.Advanced healthcare materials · 2025Review
- Atomic Force Microscopy for Cross-Disciplinary Materials Research.Small methods · 2025Review
- From Bench to Chairside: Collagen Scaffolds in Combination with Mesenchymal Stromal Cells for Gingival Augmentation.Dentistry journal · 2025Article
- Mapping single-cell rheology of ascidian embryos in the cleavage stages using AFM.Biophysical journal · 2025Article
- Article
- Revisiting the Mechanical Work-Energy Framework in Dynamic Biomechanical Systems.Bioengineering (Basel, Switzerland) · 2025Article
- Multiplexed Nanoscale Viscoelastic Mapping at Multiple Time Scales of Melanoma Cells as a Label-Free Cancer Biomarker.ACS nano · 2025Article
- High-Throughput Nanorheology of Living Cells Powered by Supervised Machine Learning.Advanced intelligent systems (Weinheim an der Bergstrasse, Germany) · 2025Article
- Nanomechanical characterization of soft nanomaterial using atomic force microscopy.Materials today. Bio · 2025Review
- Matrix degradation enhances stress relaxation, regulating cell adhesion and spreading.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Benzodiazepine-Derived Molecule That Interferes with the Bio-Mechanical Properties of Glioblastoma-Astrocytoma Cells Altering Their Proliferation and Migration.International journal of molecular sciences · 2025Article
- Non-Invasive Nanometer Resolution Assessment of Cell-Soft Hydrogel System Mechanical Properties by Scanning Ion Conductance Microscopy.International journal of molecular sciences · 2024Article
- Viscoelasticity of ECM and cells-origin, measurement and correlation.Mechanobiology in medicine · 2024Review
- Atomic force microscopy reveals morphological and mechanical properties of schistosoma mansoni tegument.Scientific reports · 2024Article
26 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Force-displacement (F-Z) curves are the most commonly used Atomic Force Microscopy (AFM) mode to measure the local, nanoscale elastic properties of soft materials like living cells. Yet a theoretical framework has been lacking that allows the post-processing of F-Z data to extract their viscoelastic constitutive parameters. Here, we propose a new method to extract nanoscale viscoelastic properties of soft samples like living cells and hydrogels directly from conventional AFM F-Z experiments, thereby creating a common platform for the analysis of cell elastic and viscoelastic properties with arbitrary linear constitutive relations. The method based on the elastic-viscoelastic correspondence principle was validated using finite element (FE) simulations and by comparison with the existed AFM techniques on living cells and hydrogels. The method also allows a discrimination of which viscoelastic relaxation model, for example, standard linear solid (SLS) or power-law rheology (PLR), best suits the experimental data. The method was used to extract the viscoelastic properties of benign and cancerous cell lines (NIH 3T3 fibroblasts, NMuMG epithelial, MDA-MB-231 and MCF-7 breast cancer cells). Finally, we studied the changes in viscoelastic properties related to tumorigenesis including TGF-β induced epithelial-to-mesenchymal transition on NMuMG cells and Syk expression induced phenotype changes in MDA-MB-231 cells.
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