ArticleScientific reports2017
A simple and cost-effective setup for super-resolution localization microscopy.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 75 citations in OpenAlex.
- Maximizing photon utilization in spectroscopic single-molecule localization microscopy using symmetrically dispersed dual-wedge prisms.Npj imaging · 2026Article
- Reinforced optical cage systems enable drift-free single-molecule localization microscopy.Communications engineering · 2025Article
- Optical super-resolution histology of formalin-fixed paraffin-embedded tissue samples: challenges and opportunities.Nature communications · 2025Review
- Super-resolution microscopy for structural biology.Nature methods · 2025Review
- Model-free machine learning-based 3D single molecule localisation microscopy.Journal of microscopy · 2025Article
- An Omni-Mesoscope for multiscale high-throughput quantitative phase imaging of cellular dynamics and high-content molecular characterization.Science advances · 2024Article
- Build and operation of a custom 3D, multicolor, single-molecule localization microscope.Nature protocols · 2024Review
- openFrame: A modular, sustainable, open microscopy platform with single-shot, dual-axis optical autofocus module providing high precision and long range of operation.Journal of microscopy · 2023Article
- Simple, Economic, and Robust Rail-Based Setup for Super-Resolution Localization Microscopy.The journal of physical chemistry. A · 2023Article
- The K2: Open-source simultaneous triple-color TIRF microscope for live-cell and single-molecule imaging.HardwareX · 2023Article
- Constructing a cost-efficient, high-throughput and high-quality single-molecule localization microscope for super-resolution imaging.Nature protocols · 2022Review
- Photon-free (s)CMOS camera characterization for artifact reduction in high- and super-resolution microscopy.Nature communications · 2022Article
- Can super-resolution microscopy become a standard characterization technique for materials chemistry?Chemical science · 2022Review
- Volumetric super-resolution imaging by serial ultrasectioning and stochastic optical reconstruction microscopy in mouse neural tissue.STAR protocols · 2021Article
- Enhanced super-resolution microscopy by extreme value based emitter recovery.Scientific reports · 2021Article
- Single-molecule localization microscopy.Nature reviews. Methods primers · 2021Article
- Towards a Quantitative Single Particle Characterization by Super Resolution Microscopy: From Virus Structures to Antivirals Design.Frontiers in bioengineering and biotechnology · 2021Review
- Super-resolution localization microscopy: Toward high throughput, high quality, and low cost.APL photonics · 2020Article
- Fast and accurate sCMOS noise correction for fluorescence microscopy.Nature communications · 2020Article
- PathSTORM: a road to early cancer detection.Molecular & cellular oncology · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
Abstract
Single molecule localization microscopy (SMLM) has become a powerful imaging tool for biomedical research, but it is mostly available in imaging facilities and a small number of laboratories due to its high cost. Here, we evaluate the possibility of replacing high-cost components on standard SMLM with appropriate low-cost alternatives and build a simple but high-performance super-resolution SMLM setup. Through numerical simulation and biological experiments, we demonstrate that our low-cost SMLM setup can yield similar localization precision and spatial resolution compared to the standard SMLM equipped with state-of-the-art components, but at a small fraction of their cost. Our low-cost SMLM setup can potentially serve as a routine laboratory microscope with high-performance super-resolution imaging capability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.