Evidence map›Paper›PMID 28484221›Full record

ArticleScientific reports2017

A novel non genomic glucocorticoid signaling mediated by a membrane palmitoylated glucocorticoid receptor cross talks with GnRH in gonadotrope cells.

Mohsen Ayrout, Violaine Simon, Valérie Bernard, Nadine Binart, Joëlle Cohen-Tannoudji, Marc Lombès, Stéphanie Chauvin

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

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  10. Variation in glucocorticoid sensitivity and the relation with obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Mohsen AyroutINSERM UMR_S1185, Fac Med Paris Sud, Université Paris-Saclay, F-94276, Le Kremlin Bicêtre, France.
Violaine SimonSorbonne Paris Cité, Université Paris-Diderot, CNRS, INSERM, Biologie Fonctionnelle et Adaptative UMR 8251, Physiologie de l'axe gonadotrope, U1133, Paris, France.
Valérie BernardINSERM UMR_S1185, Fac Med Paris Sud, Université Paris-Saclay, F-94276, Le Kremlin Bicêtre, France.
Nadine BinartINSERM UMR_S1185, Fac Med Paris Sud, Université Paris-Saclay, F-94276, Le Kremlin Bicêtre, France.
Joëlle Cohen-TannoudjiSorbonne Paris Cité, Université Paris-Diderot, CNRS, INSERM, Biologie Fonctionnelle et Adaptative UMR 8251, Physiologie de l'axe gonadotrope, U1133, Paris, France.
Marc LombèsINSERM UMR_S1185, Fac Med Paris Sud, Université Paris-Saclay, F-94276, Le Kremlin Bicêtre, France.
Stéphanie ChauvinINSERM UMR_S1185, Fac Med Paris Sud, Université Paris-Saclay, F-94276, Le Kremlin Bicêtre, France. stephanie.chauvin@inserm.fr.
Inserm · FRUniversité Paris Cité · FRUniversité Paris-Saclay · FRToxicologie, Pharmacologie et Signalisation Cellulaire · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glucocorticoid hormones (GC) are the main stress mediators associated with reproductive disorders. GC exert their effects through activation of the glucocorticoid receptor (GR) principally acting as a transcription factor. Beside well-established GR-mediated genomic actions, several lines of evidence suggest a role for rapid membrane-initiated GC signaling in gonadotrope cells triggered by a membrane-associated GR. Herein, we demonstrate the existence of a specific membrane-initiated GC signaling in LβT2 gonadotrope cells involving two related phosphoproteins: Ca

Indexed as

GenomeLipoylationSignal TransductionAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2DexamethasoneGlucocorticoidsGonadotrophsGonadotropin-Releasing HormoneHEK293 CellsHumansLuteinizing HormoneMaleMicePhosphorylationReceptors, GlucocorticoidCalcium-Calmodulin-Dependent Protein Kinase Type 2DexamethasoneGlucocorticoidsGonadotropin-Releasing HormoneLuteinizing HormoneReceptors, GlucocorticoidSynapsins

Identifiers

PMID28484221
PMCPMC5431531
OpenAlexW2611650664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.