ArticleProceedings of the National Academy of Sciences of the United States of America2017
Adaptation of cone pigments found in green rods for scotopic vision through a single amino acid mutation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 43 citations in OpenAlex.
- Evolution of a central dopamine circuit underlies adaptation of a light-evoked sensorimotor response in the blind cavefish.Science advances · 2026Article
- Evolution of a central dopamine circuit underlies adaptation of light-evoked sensorimotor response in the blind cavefish,bioRxiv : the preprint server for biology · 2024Article
- Diversity and Evolution of Frog Visual Opsins: Spectral Tuning and Adaptation to Distinct Light Environments.Molecular biology and evolution · 2024Article
- From water to land: Evolution of photoreceptor circuits for vision in air.PLoS biology · 2024Article
- Convergent evolution of animal and microbial rhodopsins.RSC advances · 2023Review
- Cell-type expression and activation by light of neuropsins in the developing and matureFrontiers in cellular neuroscience · 2023Article
- Evolutionary analyses of visual opsin genes in frogs and toads: Diversity, duplication, and positive selection.Ecology and evolution · 2022Article
- Phototransduction in Anuran Green Rods: Origins of Extra-Sensitivity.International journal of molecular sciences · 2021Article
- Eye-Transcriptome and Genome-Wide Sequencing for Scolecophidia: Implications for Inferring the Visual System of the Ancestral Snake.Genome biology and evolution · 2021Article
- Evolutionary adaptation of visual pigments in geckos for their photic environment.Science advances · 2021Article
- A closer look at pupil diversity and evolution in frogs and toads.Proceedings. Biological sciences · 2021Article
- Functional expression of the eukaryotic proton pump rhodopsin OmR2 in Escherichia coli and its photochemical characterization.Scientific reports · 2021Article
- Type II Opsins in the Eye, the Pineal Complex and the Skin ofFrontiers in neuroanatomy · 2021Review
- Evolutionary history of teleost intron-containing and intron-less rhodopsin genes.Scientific reports · 2019Article
- Diverse Cell Types, Circuits, and Mechanisms for Color Vision in the Vertebrate Retina.Physiological reviews · 2019Review
- Restoration of high-sensitivity and adapting vision with a cone opsin.Nature communications · 2019Article
- Article
- Pinopsin evolved as the ancestral dim-light visual opsin in vertebrates.Communications biology · 2018Article
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Authors and funding
11 authors at 5 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Most vertebrate retinas contain a single type of rod for scotopic vision and multiple types of cones for photopic and color vision. The retinas of certain amphibian species uniquely contain two types of rods: red rods, which express rhodopsin, and green rods, which express a blue-sensitive cone pigment (M1/SWS2 group). Spontaneous activation of rhodopsin induced by thermal isomerization of the retinal chromophore has been suggested to contribute to the rod's background noise, which limits the visual threshold for scotopic vision. Therefore, rhodopsin must exhibit low thermal isomerization rate compared with cone visual pigments to adapt to scotopic condition. In this study, we determined whether amphibian blue-sensitive cone pigments in green rods exhibit low thermal isomerization rates to act as rhodopsin-like pigments for scotopic vision. Anura blue-sensitive cone pigments exhibit low thermal isomerization rates similar to rhodopsin, whereas Urodela pigments exhibit high rates like other vertebrate cone pigments present in cones. Furthermore, by mutational analysis, we identified a key amino acid residue, Thr47, that is responsible for the low thermal isomerization rates of Anura blue-sensitive cone pigments. These results strongly suggest that, through this mutation, anurans acquired special blue-sensitive cone pigments in their green rods, which could form the molecular basis for scotopic color vision with normal red rods containing green-sensitive rhodopsin.
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