SynthesisJournal of investigative medicine : the official publication of the American Federation for Clinical Research2017
Efficacy of interventions for adherence to the immunosuppressive therapy in kidney transplant recipients: a meta-analysis and systematic review.
Synthesis in Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Effectiveness of eHealth for Medication Adherence in Renal Transplant Recipients: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- Efficacy of Adherence-Enhancing Interventions for Immunosuppressive Therapy in Solid Organ Transplant Recipients: A Systematic Review and Meta-Analysis Based on Randomized Controlled Trials.Frontiers in pharmacology · 2020Pooled it
- Pooled it
- Psychological and Psychopathological Aspects of Kidney Transplantation: A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- Effect of Acceptance and Commitment Therapy on Motivation and Adherence to Immunosuppressive Medication in Liver Transplant Recipients: A Randomized Controlled Trial.Brain and behavior · 2025Trial
- Impact of text message reminders on immunosuppressive medication adherence among kidney transplant recipients: A randomized controlled study.Journal of evaluation in clinical practice · 2025Trial
- Evaluation of medication adherence over a decade following kidney transplantation: integration of biological and self-reported data.BMC nephrology · 2026Article
- Investigation of adherence to immunosuppressive therapy and perceived social support in organ recipients.European journal of medical research · 2025Article
- Factors affecting quality of life in connective tissue disease-related interstitial lung disease.PloS one · 2025Article
- Article
- Psychosocial Diagnosis and Treatment Before and After Organ Transplantation.Deutsches Arzteblatt international · 2023Article
- Self-management in adults after solid-organ transplantation: a scoping review protocol.BMJ open · 2023Article
- Is Non-Adherence Associated with Adverse Outcomes in Kidney Transplant Recipients? The Role of Non-Adherence as a Risk and Predictor Factor for Graft Loss and Death.Patient preference and adherence · 2023Article
- Development and validation of a LASSO-based prediction model for immunosuppressive medication nonadherence in kidney transplant recipients.Renal failure · 2023Article
- Prevalence and Modifiable Factors for Holistic Non-Adherence in Renal Transplant Patients: A Cross-Sectional Study.Patient preference and adherence · 2023Article
- Improving adherence to immunosuppression after liver or kidney transplantation in individuals with impairments in personality functioning - A randomized controlled single center feasibility study.Frontiers in psychology · 2023Article
- Article
- A Multifaceted Intervention to Improve Medication Adherence in Kidney Transplant Recipients: An Exploratory Analysis of the Fidelity of the TAKE IT Trial.JMIR formative research · 2022Article
- Article
- A Randomized Controlled Trial of a Pretransplant Educational Intervention in Kidney Patients.Transplantation direct · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunosuppressive treatment regimens are complex and require ongoing self-management. Medication adherence can be difficult to achieve for several reasons. The current meta-analysis and systematic review investigated whether adherence interventions improved immunosuppressive treatment adherence in kidney transplant recipients. Medline, Cochrane, EMBASE, and Google Scholar were searched until October 17, 2016 using the following search terms: kidney transplantation, compliance, adherence, and immunosuppressive therapy. Randomized controlled trials and two-arm prospective, retrospective, and cohort studies were included. The primary outcomes were adherence rate and adherence score. Eight studies were included with a total for 546 patients. Among participants receiving intervention, the adherence rate was significantly higher than the control group (pooled OR=2.366, 95% CI 1.222 to 4.578, p=0.011). Participants in the intervention group had greater adherence scores than those in the control group (pooled standardized difference in means =1.706, 95% CI 0.346 to 3.065, p=0.014). Sensitivity analysis indicated that findings for adherence rate were robust. However, for adherence score, the significance of the association disappeared after removing one of the studies indicating the findings may have been overly influenced by this one study. Intervention programs designed to increase immunosuppressive adherence in patients with kidney transplant improve treatment adherence.
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