Evidence map›Paper›PMID 28483978›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

FGF-Dependent, Context-Driven Role for FRS Adapters in the Early Telencephalon.

Sayan Nandi, Grigoriy Gutin, Christopher A Blackwood, Nachiket G Kamatkar, Kyung W Lee, Gordon Fishell, Fen Wang, Mitchell Goldfarb, Jean M Hébert

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Interactions between Ligand-Bound EGFR and VEGFR2.Journal of molecular biology · 2021
    Article
  3. Article
  4. Notch DosageFrontiers in cell and developmental biology · 2020
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Sayan NandiDepartment of Neuroscience and jean.hebert@einstein.yu.edu sayan.nandi@einstein.yu.edu.
Grigoriy GutinDepartment of Neuroscience and.
Christopher A BlackwoodDepartment of Neuroscience and.
Nachiket G KamatkarDepartment of Neuroscience and.
Kyung W LeeDepartment of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029.
Gordon FishellSmilow Neuroscience Program, Departments of Cell Biology and Neural Science, New York University Langone Medical Center, New York, New York 10016, and.
Fen WangCenter for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas 77030.
Mitchell GoldfarbDepartment of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029.ORCID 0000-0002-7219-7645
Jean M HébertDepartment of Neuroscience and jean.hebert@einstein.yu.edu sayan.nandi@einstein.yu.edu.ORCID 0000-0003-3051-446X
Albert Einstein College of Medicine · USIcahn School of Medicine at Mount Sinai · USNYU Langone Health · USTexas A&M Health Science Center · US

Funding

Bronx-Einstein Training in Teaching and Research (BETTR), an IRACDA programK12GM102779 · NIGMS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Dianne Cox, Johanna Patricia Daily · 2012 to 2026
$9.2M
Genetic Analysis of Forebrain Patterning & NeurogenesisR01MH070596 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HEBERT, JEAN M · 2006 to 2017
$3.9M
WNTs, FGFs, and BMPs Induce and Maintain the TelencephalonR01MH083804 · NIMH · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI HEBERT, JEAN M · 2009 to 2013
$2.0M
NIGMS NIH HHS K12 GM102779NIMH NIH HHS R01 MH070596NIMH NIH HHS R01 MH083804
6 · The paper itself

Abstract

FGF signaling, an important component of intercellular communication, is required in many tissues throughout development to promote diverse cellular processes. Whether FGF receptors (FGFRs) accomplish such varied tasks in part by activating different intracellular transducers in different contexts remains unclear. Here, we used the developing mouse telencephalon as an example to study the role of the FRS adapters FRS2 and FRS3 in mediating the functions of FGFRs. Using tissue-specific and germline mutants, we examined the requirement of Frs genes in two FGFR-dependent processes. We found that

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCells, CulturedCell SurvivalFemaleFibroblast Growth FactorsMaleMiceMice, TransgenicNeural Stem CellsReceptors, Fibroblast Growth FactorTelencephalonAdaptor Proteins, Signal TransducingFibroblast Growth FactorsFrs3 protein, mouseReceptors, Fibroblast Growth FactorFRS2FRS3signaling adaptersignal transductiontelencephalon

Identifiers

PMID28483978
PMCPMC5469306
OpenAlexW2611968305

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.