Evidence map›Paper›PMID 28483976›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Targeting a Potassium Channel/Syntaxin Interaction Ameliorates Cell Death in Ischemic Stroke.

Chung-Yang Yeh, Ashlyn M Bulas, Aubin Moutal, Jami L Saloman, Karen A Hartnett, Charles T Anderson, Thanos Tzounopoulos, Dandan Sun, Rajesh Khanna, Elias Aizenman

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. NPC1-dependent alterations in KNature communications · 2023
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  11. Regulation of neuronal excitation-transcription coupling by Kv2.1-induced clustering of somatic L-type CaProceedings of the National Academy of Sciences of the United States of America · 2021
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  17. Article
  18. Voltage-Gated Potassium Channels as Regulators of Cell Death.Frontiers in cell and developmental biology · 2020
    Review
  19. Review
  20. Defining the Kv2.1-syntaxin molecular interaction identifies a first-in-class small molecule neuroprotectant.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Chung-Yang YehDepartment of Neurobiology.
Ashlyn M BulasDepartment of Neurobiology.
Aubin MoutalDepartments of Pharmacology, Anesthesiology, and Graduate Interdisciplinary Program in Neuroscience, College of Medicine, University of Arizona, Tucson, Arizona 85724.
Jami L SalomanDepartment of Neurobiology.ORCID 0000-0001-6093-6511
Karen A HartnettDepartment of Neurobiology.
Charles T AndersonDepartment of Otolaryngology, and.
Thanos TzounopoulosDepartment of Neurobiology.ORCID 0000-0003-4583-145X
Dandan SunPittsburgh Institute for Neurodegenerative Diseases.
Rajesh KhannaDepartments of Pharmacology, Anesthesiology, and Graduate Interdisciplinary Program in Neuroscience, College of Medicine, University of Arizona, Tucson, Arizona 85724.ORCID 0000-0002-9066-2969
Elias AizenmanDepartment of Neurobiology, redox@pitt.edu.
Institute for Neurodegenerative Disorders · USInstitute of Neurobiology · BGUniversity of Arizona · USUniversity of Pittsburgh · US

Funding

Liberation of Intracellular Zinc and Neuronal Cell DeathR01NS043277 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AIZENMAN, ELIAS · 2002 to 2022
$8.2M
Predoctorial Training in Basic NeuroscienceT32NS007433 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MERINEY, STEPHEN D · 1998 to 2022
$8.0M
Cell-specific Synaptic Plasticity in the Auditory BrainstemR01DC007905 · NIDCD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TZOUNOPOULOS, THANOS · 2007 to 2021
$6.9M
Liberation of Intracellular Zinc and Neuronal Cell DeathR56NS043277 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AIZENMAN, ELIAS · 2007 to 2007
$371k
NIDCD NIH HHS R01 DC007905NINDS NIH HHS R01 NS043277NINDS NIH HHS R56 NS043277NINDS NIH HHS T32 NS007433
6 · The paper itself

Abstract

The voltage-gated K

Indexed as

AnimalsApoptosisCells, CulturedDrug Delivery SystemsFemaleKv1.2 Potassium ChannelMaleNeuroprotective AgentsPotassium Channel BlockersQa-SNARE ProteinsRatsStrokeTreatment OutcomeKv1.2 Potassium ChannelNeuroprotective AgentsPotassium Channel BlockersQa-SNARE Proteinsapoptosisischemianeuroprotectionpotassium channelsyntaxinzinc

Identifiers

PMID28483976
PMCPMC5469303
OpenAlexW2612474029

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.