Evidence map›Paper›PMID 28483975›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Developmental Disruption of Recurrent Inhibitory Feedback Results in Compensatory Adaptation in the Renshaw Cell-Motor Neuron Circuit.

Anders Enjin, Sharn Perry, Markus M Hilscher, Chetan Nagaraja, Martin Larhammar, Henrik Gezelius, Anders Eriksson, Katarina E Leão, Klas Kullander

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Spinal Inhibitory Interneurons: Gatekeepers of Sensorimotor Pathways.International journal of molecular sciences · 2021
    Review
  9. Article
  10. Article
  11. Delineating the Diversity of Spinal Interneurons in Locomotor Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Anders EnjinDepartment of Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.ORCID 0000-0001-7167-9434
Sharn PerryDepartment of Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.
Markus M HilscherDepartment of Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.ORCID 0000-0001-7782-0830
Chetan NagarajaDepartment of Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.ORCID 0000-0001-9768-9462
Martin LarhammarDepartment of Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.ORCID 0000-0002-1547-6760
Henrik GezeliusDepartment of Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.ORCID 0000-0002-6242-6344
Anders ErikssonDepartment of Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.
Katarina E LeãoDepartment of Neuroscience, Uppsala University, 751 24 Uppsala, Sweden.
Klas KullanderDepartment of Neuroscience, Uppsala University, 751 24 Uppsala, Sweden klas.kullander@neuro.uu.se.ORCID 0000-0001-6418-5460
Uppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

When activating muscles, motor neurons in the spinal cord also activate Renshaw cells, which provide recurrent inhibitory feedback to the motor neurons. The tight coupling with motor neurons suggests that Renshaw cells have an integral role in movement, a role that is yet to be elucidated. Here we used the selective expression of the nicotinic cholinergic receptor α2 (

Indexed as

Adaptation, PhysiologicalAgingAnimalsCells, CulturedFeedback, PhysiologicalFemaleMaleMiceMice, Inbred C57BLMice, KnockoutMotor NeuronsNeural InhibitionNeural PathwaysNeuronal PlasticityRenshaw CellsSynapsesChATChrna2mousespinal cordVIAAT

Identifiers

PMID28483975
PMCPMC6596475
OpenAlexW2612111329

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.