Evidence map›Paper›PMID 28483966›Full record

ArticleAntimicrobial agents and chemotherapy2017

Synergistic Efficacy of Aedes aegypti Antimicrobial Peptide Cecropin A2 and Tetracycline against Pseudomonas aeruginosa.

Zhaojun Zheng, Nagendran Tharmalingam, Qingzhong Liu, Elamparithi Jayamani, Wooseong Kim, Beth Burgwyn Fuchs, Rijun Zhang, Andreas Vilcinskas, Eleftherios Mylonakis

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 73 citations in OpenAlex.

  1. Synergistic Antibacterial and Antibiofilm Effects of (KW)Journal of peptide science : an official publication of the European Peptide Society · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Mechanisms ofMedicina (Kaunas, Lithuania) · 2026
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Anti-Frontiers in microbiology · 2023
    Review
  16. Article
  17. Article
  18. Advances and perspectives for antimicrobial peptide and combinatory therapies.Frontiers in bioengineering and biotechnology · 2022
    Review
  19. Article
  20. Frontiers in cellular and infection microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Zhaojun ZhengDivision of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Nagendran TharmalingamDivision of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Qingzhong LiuDivision of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Elamparithi JayamaniDivision of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, USA.ORCID 0000-0003-1704-079X
Wooseong KimDivision of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Beth Burgwyn FuchsDivision of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Rijun ZhangState Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Andreas VilcinskasInstitute for Insect Biotechnology, Justus-Liebig University, Giessen, Germany.
Eleftherios MylonakisDivision of Infectious Diseases, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, Rhode Island, USA emylonakis@lifespan.org.ORCID 0000-0002-4624-0777
Brown University · USChina Agricultural University · CNJustus-Liebig-Universität Gießen · DE

Funding

Technical Mother Machine CoreP01AI083214 · NIAID · SCHEPENS EYE RESEARCH INSTITUTE · PI Michael S Gilmore · 2009 to 2026
$39.4M
NIAID NIH HHS P01 AI083214
6 · The paper itself

Abstract

The increasing prevalence of antibiotic resistance has created an urgent need for alternative drugs with new mechanisms of action. Antimicrobial peptides (AMPs) are promising candidates that could address the spread of multidrug-resistant bacteria, either alone or in combination with conventional antibiotics. We studied the antimicrobial efficacy and bactericidal mechanism of cecropin A2, a 36-residue α-helical cationic peptide derived from

Indexed as

AedesAnimalsAnti-Bacterial AgentsCecropinsDrug SynergismErythrocytesGram-Negative BacteriaHep G2 CellsHumansMicrobial Sensitivity TestsPseudomonas aeruginosaTetracyclineAnti-Bacterial AgentsCecropinsTetracyclineantimicrobial activityantimicrobial peptidececropin A2Pseudomonas aeruginosatetracycline

Identifiers

PMID28483966
PMCPMC5487646
OpenAlexW2612326264

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.