Evidence map›Paper›PMID 28483963›Full record

ArticleAntimicrobial agents and chemotherapy2017

Influence of Experimental Cryptococcal Meningitis in Wistar Rats on Voriconazole Brain Penetration Assessed by Microdialysis.

Izabel Almeida Alves, Keli Jaqueline Staudt, Carolina de Miranda Silva, Graziela de Araujo Lock, Teresa Dalla Costa, Bibiana Verlindo de Araujo

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Cryptococcus spp. and Cryptococcosis: focusing on the infection in Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022
    Review
  6. Concurrent infection withExperimental and therapeutic medicine · 2020
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Izabel Almeida AlvesPharmaceutical Sciences Graduate Program of Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Keli Jaqueline StaudtMedical Sciences Graduate Program of Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Carolina de Miranda SilvaPharmaceutical Sciences Graduate Program of Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Graziela de Araujo LockPharmaceutical Sciences Graduate Program of Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Teresa Dalla CostaPharmaceutical Sciences Graduate Program of Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Bibiana Verlindo de AraujoPharmaceutical Sciences Graduate Program of Federal University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil bibiana.araujo@ufrgs.br.
Universidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To make advances in the treatment of cryptococcal meningitis, it is crucial to know a given drug's free fraction that reaches the biophase. In the present study, we applied microdialysis (μD) as a tool to determine the free levels reached by voriconazole (VRC) in the brains of healthy and

Indexed as

AnimalsBrainCryptococcus neoformansMaleMeningitis, CryptococcalMicrodialysisRatsRats, WistarVoriconazoleVoriconazoleCryptococcus neoformansmeningitismicrodialysispopulation pharmacokinetics analysisvoriconazole

Identifiers

PMID28483963
PMCPMC5487622
OpenAlexW2614048200

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.