Evidence map›Paper›PMID 28483961›Full record

ArticleAntimicrobial agents and chemotherapy2017

Efficacy of Ceftaroline against Methicillin-Susceptible Staphylococcus aureus Exhibiting the Cefazolin High-Inoculum Effect in a Rat Model of Endocarditis.

Kavindra V Singh, Truc T Tran, Esteban C Nannini, Vincent H Tam, Cesar A Arias, Barbara E Murray

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Evolution under vancomycin selection drives divergent collateral sensitivity patterns inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. The Application of Rat Models inPathogens (Basel, Switzerland) · 2024
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Cefazolin and Ertapenem Salvage Therapy Rapidly Clears Persistent Methicillin-Susceptible Staphylococcus aureus Bacteremia.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  13. Article
  14. Article
  15. Article
  16. Inoculum effect of β-lactam antibiotics.The Journal of antimicrobial chemotherapy · 2019
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Kavindra V SinghDivision of Infectious Diseases, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA Kavindra.singh@uth.tmc.edu.
Truc T TranDivision of Infectious Diseases, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Esteban C NanniniDivision of Infectious Diseases, School of Medicine, Universidad Nacional de Rosario,. Instituto de Inmunología Clínica y Experimental Rosario (IDICER), CONICET, Rosario, Argentina.
Vincent H TamCollege of Pharmacy, University of Houston, Houston, Texas, USA.
Cesar A AriasDivision of Infectious Diseases, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Barbara E MurrayDivision of Infectious Diseases, Department of Internal Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA.
The University of Texas Health Science Center at Houston · USInstituto de Biología Molecular y Celular de Rosario · ARUniversity of Houston · US

Funding

Alternative Approaches for E. faecalis InfectionsR01AI047923 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MURRAY, BARBARA E · 2010 to 2014
$3.1M
Molecular Mechanisms Of Daptomycin Resistance In EnterococciR01AI093749 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2011 to 2015
$1.9M
POR Program on Genomic Prediction of Antimicrobial Resistance in VREK24AI121296 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2016 to 2025
$1.5M
Daptomycin Resistance in Enterococcus faeciumK08AI113317 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI TRAN, TRUC THANH · 2014 to 2018
$792k
Molecular basis of the cefazolin inoculum effectR21AI143229 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2019 to 2020
$442k
Targeting Cell Membrane Adaptation in Multidrug-Resistant Enterococcus faeciumR21AI121519 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ARIAS, CESAR AUGUSTO · 2016 to 2017
$226k
NIAID NIH HHS K08 AI113317NIAID NIH HHS K24 AI121296NIAID NIH HHS R01 AI047923NIAID NIH HHS R01 AI093749NIAID NIH HHS R21 AI121519NIAID NIH HHS R21 AI143229
6 · The paper itself

Abstract

Certain

Indexed as

AnimalsAnti-Bacterial Agentsbeta-LactamasesBody WeightCefazolinCeftarolineCephalosporinsEndocarditisMaleMethicillinMicrobial Sensitivity TestsNafcillinRatsRats, Sprague-DawleyStaphylococcus aureusAnti-Bacterial Agentsbeta-LactamasesCefazolinCeftarolineCephalosporinsMethicillinNafcillinceftarolineendocarditisStaphylococcus aureusβ-lactamase

Identifiers

PMID28483961
PMCPMC5487651
OpenAlexW2613508738

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.