ArticleMolecular cancer research : MCR2017
p53 Maintains Baseline Expression of Multiple Tumor Suppressor Genes.
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In one paragraph
Article in Molecular cancer research : MCR, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 75 citations in OpenAlex.
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- AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells.Cell reports · 2023Article
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- Sesquiterpene Lactones Potentiate Olaparib-Induced DNA Damage in p53 Wildtype Cancer Cells.International journal of molecular sciences · 2022Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 4 institutions in 2 countries.
Kyrie PappasDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Jia XuDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Sakellarios ZairisDepartment of Systems Biology, Columbia University Medical Center, New York, New York.
Lois Resnick-SilvermanDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Francesco AbateDepartment of Systems Biology, Columbia University Medical Center, New York, New York.
Nicole SteinbachDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Sait OzturkDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Lao H SaalDivision of Oncology and Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden.
Tao SuDepartment of Pathology, Columbia University Medical Center, New York, New York.
Pamela CheungDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Hank SchmidtThe Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York.
Stuart AaronsonDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Hanina HibshooshDepartment of Pathology, Columbia University Medical Center, New York, New York.
James ManfrediDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Raul RabadanDepartment of Systems Biology, Columbia University Medical Center, New York, New York.
Ramon ParsonsDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York. ramon.parsons@mssm.edu.
Columbia University Irving Medical Center · USTisch Hospital · USLund University · SEMount Sinai Hospital · US
Funding
THE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Deanna L Benson · 2015 to 2026
$35.4MPW1--A mediator of cell survival by NFKB and cell death by p53P01CA080058 · NCI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI AARONSON, STUART A · 2000 to 2016
$20.2MTRAINING PROGRAM IN CANCER THERAPYT32CA078207 · NCI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI James J Manfredi · 1999 to 2026
$11.6MTopology of Cancer Evolution and HeterogeneityU54CA193313 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI IAVARONE, ANTONIO, RABADAN, RAUL · 2015 to 2020
$10.4MPTEN and CancerR35CA220491 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PARSONS, RAMON E · 2017 to 2023
$6.8MPTEN TUMOR SUPPRESSOR AND SIGNAL TRANSDUCTIONR01CA082783 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PARSONS, RAMON E · 2001 to 2016
$3.8MTissue-specific tumor suppressor effects of p53R01CA200256 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MANFREDI, JAMES J · 2015 to 2019
$2.3MMechanisms of PTEN-Long Function in CancerR01CA184016 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PARSONS, RAMON E · 2014 to 2017
$1.4MClinical and Translational Science AwardTL1TR000082 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$732kMolecular mechanisms of transcriptional repression of PTEN in human breast cancerF31CA183268 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI PAPPAS, KYRIE JEAN · 2014 to 2016
$127kNCATS NIH HHS TL1 TR000082NCI NIH HHS F31 CA183268NCI NIH HHS P01 CA080058NCI NIH HHS P30 CA196521NCI NIH HHS R01 CA082783NCI NIH HHS R01 CA184016NCI NIH HHS R01 CA200256NCI NIH HHS R35 CA220491NCI NIH HHS T32 CA078207NCI NIH HHS U54 CA193313
Abstract
PubMed holds no abstract for this paper.
Indexed as
AMP-Activated Protein Kinase KinasesBinding SitesCell Line, TumorCell Transformation, NeoplasticForkhead Box Protein O1Gene Expression Regulation, NeoplasticHaploinsufficiencyHistone DemethylasesHumansMicroRNAsMutationNeoplasmsNuclear ProteinsProtein BindingProtein Serine-Threonine KinasesPTEN PhosphohydrolaseAMP-Activated Protein Kinase KinasesForkhead Box Protein O1FOXO1 protein, humanHistone DemethylasesKDM6A protein, humanMicroRNAsMIRN34 microRNA, humanNuclear ProteinsProtein Serine-Threonine KinasesPTEN PhosphohydrolasePTEN protein, humanReceptors, TNF-Related Apoptosis-Inducing LigandSTK11 protein, humanTNFRSF10B protein, humanTP53 protein, humanTSSC3 proteinTumor Suppressor Protein p53Tumor Suppressor Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.