ArticleThe Journal of biological chemistry2017
Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice.
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Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
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Who cites it
54 citing papers in PubMed, 97 citations in OpenAlex.
- Hepatic Overexpression of a Novel Soluble Endogenous Transforming Growth Factor β Type II Receptor-Immunoglobulin G1 Fc Fusion Protein (TβRII-SE/Fc) Attenuates Early Stage Metabolic Dysfunction-Associated Steatotic Liver Disease in Rats.ACS pharmacology & translational science · 2026Article
- GLP-1 receptor agonists in metabolic dysfunction-associated steatotic liver disease: mechanistic networks and translational implications: a review.Journal of endocrinological investigation · 2026Review
- Rapid Metabolic and Behavioral Maladaptations Following Short-Term Obesogenic Diet Withdrawal During Postweaning Development in Male Wistar Rats.Brain and behavior · 2026Article
- Acai Supplementation and Resistance Training: A Preliminary Study of the Effects on Liver Parameters in Hypertensive Rats.Life (Basel, Switzerland) · 2026Article
- Article
- Twelve weeks of voluntary wheel running restores glucagon sensitivity in middle-aged mice.American journal of physiology. Endocrinology and metabolism · 2026Article
- Glycogen metabolic dysfunction in T2DM with MASLD: linking α-hydroxybutyrate to GYS2 downregulation.Frontiers in nutrition · 2026Article
- Unlocking the potential of atractylenolide II: Mitigating non-alcoholic fatty liver disease through farnesoid X receptor-endoplasmic reticulum stress interplay.Journal of pharmaceutical analysis · 2025Article
- Hepatocytic ankyrin repeat and SOCS box protein 3 deficiency alleviates metabolic dysfunction-associated steatotic liver disease by decreasing ubiquitin-mediated carnitine palmitoyl transferase 1A.Clinical and molecular hepatology · 2025Article
- A Plant-Based Strategy for MASLD:International journal of molecular sciences · 2025Article
- Resveratrol Impairs Insulin Signaling in Hepatic Cells via Activation of PKC and PTP1B Pathways.International journal of molecular sciences · 2025Article
- Fasting-Induced Hepatic Gluconeogenesis Is Compromised In Anxa6Journal of cellular physiology · 2025Article
- GLP-1 and Its Role in Glycogen Production: A Narrative Review.Biomedicines · 2025Review
- Integrated liver-secreted and plasma proteomics identify a predictive model that stratifies MASH.Cell reports. Medicine · 2025Article
- Article
- Association of the triglyceride glucose-waist height ratio with asymptomatic intracranial arterial stenosis.Lipids in health and disease · 2025Article
- Tacrolimus induces insulin receptor substrate 1 hyperphosphorylation and inhibits mTORc1/S6K1 cascade in HL7702 cells.World journal of diabetes · 2025Article
- From NAFLD to NASH: Understanding the spectrum of non-alcoholic liver diseases and their consequences.Heliyon · 2024Review
- Obesogenic Diet in Mice Leads to Inflammation and Oxidative Stress in the Mother in Association with Sex-Specific Changes in Fetal Development, Inflammatory Markers and Placental Transcriptome.Antioxidants (Basel, Switzerland) · 2024Article
- Synthesis and biological evaluation of the novel chrysin prodrug for non-alcoholic fatty liver disease treatment.Frontiers in pharmacology · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Jose M IrimiaFrom the Departments of Biochemistry and Molecular Biology and.
Catalina M MeyerFrom the Departments of Biochemistry and Molecular Biology and.
Dyann M SegvichFrom the Departments of Biochemistry and Molecular Biology and.
Sneha SurendranMedical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Anna A DePaoli-RoachFrom the Departments of Biochemistry and Molecular Biology and.
Nuria MorralMedical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202.
Peter J RoachFrom the Departments of Biochemistry and Molecular Biology and proach@iupui.edu.
Indiana University – Purdue University Indianapolis · USIndiana University School of Medicine
Funding
Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4MHORMONAL CONTROL OF GLYCOGEN METABOLISMR37DK027221 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI ROACH, PETER J · 1992 to 2014
$5.2MSMALL MOLECULE INHIBITION OF GLYCOGEN STORAGE AS THERAPY FOR GLYCOGENOSESR01DK027221 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI HURLEY, THOMAS D. · 1986 to 2020
$4.4MGlycogen Metabolism and Lafora DiseaseR01NS056454 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI ROACH, PETER J · 2009 to 2018
$3.4MSMALL MOLECULE INHIBITION OF GLYCOGEN STORAGE AS THERAPY FOR GLYCOGENOSESR56DK027221 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI HURLEY, THOMAS D., ROACH, PETER J · 2015 to 2015
$185kNIDDK NIH HHS P30 DK097512NIDDK NIH HHS R01 DK027221NIDDK NIH HHS R37 DK027221NIDDK NIH HHS R56 DK027221NINDS NIH HHS R01 NS056454
Abstract
Disruption of the
Indexed as
Insulin ResistanceSignal TransductionAcetyl-CoA CarboxylaseActive Transport, Cell NucleusAnimalsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsCell NucleusFatty LiverForkhead Box Protein O1GlycogenGlycogen Synthase Kinase 3HepatocytesInsulin Receptor Substrate ProteinsMiceMice, KnockoutNuclear ProteinsAcetyl-CoA CarboxylaseBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsForkhead Box Protein O1Foxo1 protein, mouseGlycogenGlycogen Synthase Kinase 3Insulin Receptor Substrate ProteinsIrs1 protein, mouseMlxipl protein, mouseNuclear ProteinsProto-Oncogene Proteins c-aktSrebf1 protein, mouseSterol Regulatory Element Binding Protein 1Transcription Factorsfatty acid metabolismfatty liverglycogenglycogen storage diseaseinsulin resistancelipogenesis
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.