Evidence map›Paper›PMID 28483914›Full record

ArticleMolecular and cellular biology2017

Tfe3 and Tfeb Transcriptionally Regulate Peroxisome Proliferator-Activated Receptor γ2 Expression in Adipocytes and Mediate Adiponectin and Glucose Levels in Mice.

Nunciada Salma, Jun S Song, Akinori Kawakami, Suprabha P Devi, Mehdi Khaled, José M Cacicedo, David E Fisher

Erratum issuedAbstract read
In one paragraph

Article in Molecular and cellular biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Nunciada SalmaDepartment of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Jun S SongInstitute for Genomic Biology, University of Illinois, Urbana-Champaign, Urbana, Illinois, USA.
Akinori KawakamiDepartment of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Suprabha P DeviDepartment of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Mehdi KhaledGustave Roussy, INSERM U753, Villejuif, France.
José M CacicedoDiabetes and Metabolism Unit, Department of Medicine Section of Endocrinology, Boston University School of Medicine, Boston, Massachusetts, USA.
David E FisherDepartment of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA dfisher3@partners.org.

Funding

The MITF transcriptional network: melanoma risk and carcinogenesisR01AR043369 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI DAVID E FISHER · 1996 to 2026
$9.4M
Predicting Transcriptional and Epigenetic Networks in Cancer from Sequencing DataR01CA163336 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Jun S Song · 2012 to 2026
$4.4M
Role of beta-endorphin in cancer therapy induced fatigueR01CA150226 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI FISHER, DAVID E · 2011 to 2015
$1.7M
NCI NIH HHS R01 CA150226NCI NIH HHS R01 CA163336NIAMS NIH HHS R01 AR043369
6 · The paper itself

Abstract

Members of the MiT transcription factor family are pivotal regulators of several lineage-selective differentiation programs. We show that two of these, Tfeb and Tfe3, control the regulator of adipogenesis, peroxisome proliferator-activated receptor γ2 (Pparγ2). Knockdown of Tfeb or Tfe3 expression during

Indexed as

Transcriptional Activation3T3-L1 CellsAdipogenesisAdiponectinAnimalsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsEnergy MetabolismFemaleMaleMiceMice, Inbred C57BLMice, KnockoutPPAR gammaPromoter Regions, GeneticUp-RegulationAdiponectinBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsPPAR gammaTcfe3 protein, mouseTcfeb protein, mouseadipocytedevelopmentPparγTfe3Tfe3KO mouseTfebtranscription

Identifiers

PMID28483914
PMCPMC5514458

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.