Evidence map›Paper›PMID 28483721›Full record

ArticleNeuroImage2017

Large-scale sparse functional networks from resting state fMRI.

Hongming Li, Theodore D Satterthwaite, Yong Fan

Abstract read
In one paragraph

Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Review
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  11. Reproducible sex differences in personalised functional network topography in youth.The British journal of psychiatry : the journal of mental science · 2025
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  12. Article
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  18. Towards personalized precision functional mapping in infancy.Imaging neuroscience (Cambridge, Mass.) · 2024
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  19. bioRxiv : the preprint server for biology · 2024
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hongming LiCenter for Biomedical Image Computing and Analytics, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Theodore D SatterthwaiteDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yong FanCenter for Biomedical Image Computing and Analytics, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: yong.fan@ieee.org.

Funding

Personalized Functional Network Modeling to Characterize and Predict Psychopathology in YouthR01EB022573 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Yong Fan, Theodore Satterthwaite · 2016 to 2026
$6.0M
Center for the Development of Novel Medications for Cocaine DependenceU54DA039002 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI KAMPMAN, KYLE MATTHEW · 2014 to 2018
$5.1M
Cancer imaging phenomics software suite: application to brain and breast cancerU24CA189523 · NCI · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS, KONTOS, DESPINA · 2015 to 2019
$3.2M
Longitudinal multi-modal neuroimaging of irritability in youthR01MH107703 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI SATTERTHWAITE, THEODORE · 2015 to 2018
$2.6M
Targeting dopamine D3 receptors in cocaine addictionR01DA039215 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI CHILDRESS, ANNA ROSE · 2016 to 2019
$2.5M
NCI NIH HHS U24 CA189523NIBIB NIH HHS R01 EB022573NIDA NIH HHS R01 DA039215NIDA NIH HHS U54 DA039002NIMH NIH HHS R01 MH107703
6 · The paper itself

Abstract

Delineation of large-scale functional networks (FNs) from resting state functional MRI data has become a standard tool to explore the functional brain organization in neuroscience. However, existing methods sacrifice subject specific variation in order to maintain the across-subject correspondence necessary for group-level analyses. In order to obtain subject specific FNs that are comparable across subjects, existing brain decomposition techniques typically adopt heuristic strategies or assume a specific statistical distribution for the FNs across subjects, and therefore might yield biased results. Here we present a novel data-driven method for detecting subject specific FNs while establishing group level correspondence. Our method simultaneously computes subject specific FNs for a group of subjects regularized by group sparsity, to generate subject specific FNs that are spatially sparse and share common spatial patterns across subjects. Our method is built upon non-negative matrix decomposition techniques, enhanced by a data locality regularization term that makes the decomposition robust to imaging noise and improves spatial smoothness and functional coherences of the subject specific FNs. Our method also adopts automatic relevance determination techniques to eliminate redundant FNs in order to generate a compact set of informative sparse FNs. We have validated our method based on simulated, task fMRI, and resting state fMRI datasets. The experimental results have demonstrated our method could obtain subject specific, sparse, non-negative FNs with improved functional coherence, providing enhanced ability for characterizing the functional brain of individual subjects.

Indexed as

AlgorithmsBrainBrain MappingHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingModels, NeurologicalNeural PathwaysCollaborative decompositionFunctional networksInter-subject correspondenceSubject-specific networks

Identifiers

PMID28483721
PMCPMC5568802

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.