Evidence map›Paper›PMID 28483498›Full record

Trial reportContemporary clinical trials2017

Design of a randomized trial to determine the optimum protein intake to preserve lean body mass and to optimize response to a promyogenic anabolic agent in older men with physical functional limitation.

Shalender Bhasin, Caroline M Apovian, Thomas G Travison, Karol Pencina, Grace Huang, Lynn L Moore, Wayne W Campbell, Andrew Howland, Ruo Chen, Martha R Singer and 11 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Contemporary clinical trials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 1 country.

Shalender BhasinResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center for Function Promoting Therapies, Brigham and Women's Hospital, United States. Electronic address: sbhasin@partners.org.
Caroline M ApovianSection of Endocrinology, Diabetes and Nutrition, Boston Medical Center, United States.
Thomas G TravisonInstitute for Aging Research, Hebrew SeniorLife, Division of Gerontology, Beth Israel Deaconess Medical Center, United States.
Karol PencinaResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center for Function Promoting Therapies, Brigham and Women's Hospital, United States.
Grace HuangResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center for Function Promoting Therapies, Brigham and Women's Hospital, United States.
Lynn L MooreSection of Preventive Medicine and Epidemiology, Boston Medical Center, Boston, MA, United States.
Wayne W CampbellDepartment of Nutrition Science, Purdue University, West Lafayette, IN, United States.
Andrew HowlandResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center for Function Promoting Therapies, Brigham and Women's Hospital, United States.
Ruo ChenResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center for Function Promoting Therapies, Brigham and Women's Hospital, United States.
Martha R SingerInstitute for Aging Research, Hebrew SeniorLife, Division of Gerontology, Beth Israel Deaconess Medical Center, United States.
Mitali ShahSection of Endocrinology, Diabetes and Nutrition, Boston Medical Center, United States.
Richard EderResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center for Function Promoting Therapies, Brigham and Women's Hospital, United States.
Haley SchramResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center for Function Promoting Therapies, Brigham and Women's Hospital, United States.
Richelle BearupResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center for Function Promoting Therapies, Brigham and Women's Hospital, United States.
Yusnie M BelevaResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center for Function Promoting Therapies, Brigham and Women's Hospital, United States.
Ashley C McCarthySection of Endocrinology, Diabetes and Nutrition, Boston Medical Center, United States.
Zhouying LiResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center for Function Promoting Therapies, Brigham and Women's Hospital, United States.
Erin WoodburyResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center for Function Promoting Therapies, Brigham and Women's Hospital, United States.
Jennifer McKinnonResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center for Function Promoting Therapies, Brigham and Women's Hospital, United States.
Thomas W StorerResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center for Function Promoting Therapies, Brigham and Women's Hospital, United States.
Shehzad BasariaResearch Program in Men's Health: Aging and Metabolism, Boston Claude D. Pepper Older Americans Independence Center for Function Promoting Therapies, Brigham and Women's Hospital, United States.
Brigham and Women's Hospital · USBoston Medical Center · USBeth Israel Deaconess Medical Center · USPurdue University West Lafayette · US

Funding

Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2M
TUFTS--FIELDINGP30AG031679 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LEWIS LIPSITZ · 2008 to 2026
$23.9M
Optimizing Protein Intake in Older Americans with Mobility LimitationsR01AG037547 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI APOVIAN, CAROLINE M, BHASIN, SHALENDER · 2010 to 2014
$4.1M
NCATS NIH HHS UL1 TR001102NIA NIH HHS P30 AG031679NIA NIH HHS R01 AG037547
6 · The paper itself

Abstract

The dietary protein allowance for older men to maintain lean body mass and muscle strength and to accrue optimal anabolic responses to promyogenic stimuli is poorly characterized. The OPTIMEN trial was designed to assess in older men with moderate physical dysfunction and insufficient habitual protein intake (<recommended dietary allowance, RDA, 0.8g·kg

Indexed as

Absorptiometry, PhotonAgedAndrogensBody CompositionBody Mass IndexDietary ProteinsDouble-Blind MethodEnergy IntakeHumansMaleMuscle, SkeletalMuscle StrengthResearch DesignTestosteroneAndrogensDietary ProteinsTestosteronetestosterone enanthate

Identifiers

PMID28483498
PMCPMC6110262
OpenAlexW2610912672

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.