Evidence map›Paper›PMID 28483377›Full record

ArticleTrends in biochemical sciences2017

Most Alternative Isoforms Are Not Functionally Important.

Michael L Tress, Federico Abascal, Alfonso Valencia

Abstract readLetterComment
In one paragraph

Article in Trends in biochemical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed.

  1. Article
  2. Ancestral splice variation is a key substrate for rapid diversification in African cichlids.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Review
  4. Article
  5. Precision Profiling of the Cardiovascular Post-Translationally Modified Proteome.Journal of cardiovascular development and disease · 2026
    Review
  6. Article
  7. Article
  8. Impact of protein degradation and cell growth on mammalian proteomes.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Global impact of aberrant splicing on human gene expression levels.bioRxiv : the preprint server for biology · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Michael L TressDepartment of Structural and Computational Biology, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain. Electronic address: mtress@cnio.es.
Federico AbascalWellcome Trust Sanger Institute, Hinxton, UK.
Alfonso ValenciaCurrent address: Life Sciences Department, Barcelona Supercomputing Center (BSC-CNS), 08034 Barcelona, Spain.

Funding

GENCODE Resource ProjectU41HG007234 · NHGRI · SANGER INSTITUTE · PI FLICEK, PAUL · 2013 to 2020
$20.3M
NHGRI NIH HHS U41 HG007234
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Alternative SplicingHumansProtein IsoformsProtein Isoformsalternative splicingbiological complexitymass spectrometryselection

Identifiers

PMID28483377
PMCPMC6449685

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.