ArticleThe Journal of thoracic and cardiovascular surgery2017
Lungs donated after circulatory death and prolonged warm ischemia are transplanted successfully after enhanced ex vivo lung perfusion using adenosine A2B receptor antagonism.
Article in The Journal of thoracic and cardiovascular surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A meta-analysis of perfusion parameters affecting weight gain in ex vivo perfusion.Artificial organs · 2025Pooled it
- Resilience of lung grafts to warm ischemia: assessment byTransplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Contributions, bias, and research gaps in large animal ex vivo lung perfusion models: A systematic review.JHLT open · 2025Review
- Review
- Review
- The endothelium: gatekeeper to lung ischemia-reperfusion injury.Respiratory research · 2024Review
- Experimental Models of Ischemic Lung Damage for the Study of Therapeutic Reconditioning During Ex Vivo Lung Perfusion.Transplantation direct · 2022Article
- Ex-vivo lung perfusion therapies: do they add value to organ donation?Current opinion in organ transplantation · 2022Review
- Novel approaches for long-term lung transplant survival.Frontiers in immunology · 2022Review
- Gene Therapy: Will the Promise of Optimizing Lung Allografts Become Reality?Frontiers in immunology · 2022Review
- The potential of ex vivo lung perfusion on improving organ quality and ameliorating ischemia reperfusion injury.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021Review
- Donation after circulatory death donors in lung transplantation.Journal of thoracic disease · 2021Review
- Review
- Isolated Lung Perfusion in the Management of Acute Respiratory Distress Syndrome.International journal of molecular sciences · 2020Review
- Extracellular nucleotide signaling in solid organ transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020Review
- DCD lungs: is it all the same?Annals of cardiothoracic surgery · 2020Article
- Reduced-flow ex vivo lung perfusion to rehabilitate lungs donated after circulatory death.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2020Article
- Adenosine 2A Receptor Activation Attenuates Ischemia Reperfusion Injury During Extracorporeal Cardiopulmonary Resuscitation.Annals of surgery · 2019Article
- Ex Vivo Assessment of Porcine Donation After Circulatory Death Lungs That Undergo Increasing Warm Ischemia Times.Transplantation direct · 2018Article
- Early Graft Dysfunction after Lung Transplantation.Current pulmonology reports · 2018Article
Corrections and comments
- Commented on byDiscussion.2017
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Authors and funding
10 authors.
Funding
Abstract
objectiveThe current supply of acceptable donor lungs is not sufficient for the number of patients awaiting transplantation. We hypothesized that ex vivo lung perfusion (EVLP) with targeted drug therapy would allow successful rehabilitation and transplantation of donation after circulatory death lungs exposed to 2 hours of warm ischemia.
methodsDonor porcine lungs were procured after 2 hours of warm ischemia postcardiac arrest and subjected to 4 hours of cold preservation or EVLP. ATL802, an adenosine A
resultsEVLP + ATL802 significantly improved dynamic lung compliance compared with EVLP (25.0 ± 1.8 vs 17.0 ± 2.4 mL/cmH
conclusionsSeverely injured donation after circulatory death lungs subjected to 2 hours of warm ischemia are transplanted successfully after enhanced EVLP with targeted drug therapy. Increased use of lungs after uncontrolled donor cardiac death and prolonged warm ischemia may be possible and may improve transplant wait list times and mortality.
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