Evidence map›Paper›PMID 28483199›Full record

ArticleVaccine2017

A prime-boost immunization regimen based on a simian adenovirus 36 vectored multi-stage malaria vaccine induces protective immunity in mice.

Jairo A Fonseca, Jessica N McCaffery, Elena Kashentseva, Balwan Singh, Igor P Dmitriev, David T Curiel, Alberto Moreno

Open access · greenAbstract read
In one paragraph

Article in Vaccine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Frontiers in cellular and infection microbiology · 2025
    Review
  4. Article
  5. Advances in Alpha-1 Antitrypsin Gene Therapy.American journal of respiratory cell and molecular biology · 2020
    Review
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jairo A FonsecaEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, United States; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30307, United States.
Jessica N McCafferyEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, United States.
Elena KashentsevaCancer Biology Division, Department of Radiation Oncology, Washington University School of Medicine, 660 S. Euclid Ave., 4511 Forest Park Blvd, St. Louis, MO 63108, United States.
Balwan SinghEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, United States.
Igor P DmitrievCancer Biology Division, Department of Radiation Oncology, Washington University School of Medicine, 660 S. Euclid Ave., 4511 Forest Park Blvd, St. Louis, MO 63108, United States.
David T CurielCancer Biology Division, Department of Radiation Oncology, Washington University School of Medicine, 660 S. Euclid Ave., 4511 Forest Park Blvd, St. Louis, MO 63108, United States.
Alberto MorenoEmory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, United States; Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30307, United States. Electronic address: alberto.moreno@emory.edu.
Emory University · USWashington University in St. Louis · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
YNPRC NHP CLINICAL MEDICINE RESIDENCY PROGRAM - SUPPLEMENTP51RR000165 · NCRR · EMORY UNIVERSITY · PI RENGARAJAN, JYOTHI · 1985 to 2011
$114.0M
Optimization of chimeric multi-stage immunogens for malaria vaccine developmentR56AI103382 · NIAID · EMORY UNIVERSITY · PI MORENO, ALBERTO · 2014 to 2014
$844k
Coadministration of capsid modified adenovirus for malaria vaccine developmentR21AI095718 · NIAID · EMORY UNIVERSITY · PI MORENO, ALBERTO · 2012 to 2013
$490k
Novel DC targeted adenovirus vector for malaria vaccine developmentR21AI117459 · NIAID · EMORY UNIVERSITY · PI MORENO, ALBERTO · 2016 to 2017
$486k
NCRR NIH HHS P51 RR000165NIAID NIH HHS R21 AI095718NIAID NIH HHS R21 AI117459NIAID NIH HHS R56 AI103382NIH HHS P51 OD011132
6 · The paper itself

Abstract

Malaria remains a considerable burden on public health. In 2015, the WHO estimates there were 212 million malaria cases causing nearly 429,000 deaths globally. A highly effective malaria vaccine is needed to reduce the burden of this disease. We have developed an experimental vaccine candidate (PyCMP) based on pre-erythrocytic (CSP) and erythrocytic (MSP1) stage antigens derived from the rodent malaria parasite P. yoelii. Our protein-based vaccine construct induces protective antibodies and CD4

Indexed as

Adenoviruses, SimianAnimalsAntibodies, ProtozoanAntigens, ProtozoanCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesGenetic VectorsHumansImmunity, CellularImmunization, SecondaryMalariaMalaria VaccinesMiceProtozoan ProteinsAntibodies, ProtozoanAntigens, ProtozoanMalaria VaccinesProtozoan ProteinsHeterologous prime-boost regimensMalariaPlasmodium yoeliiProtein vaccineSimian adenovirusViral vectored vaccine

Identifiers

PMID28483199
PMCPMC5522619
OpenAlexW2610700356

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.