Evidence map›Paper›PMID 28483194›Full record

ArticleVaccine2017

Co-localization of a CD1d-binding glycolipid with an adenovirus-based malaria vaccine for a potent adjuvant effect.

Xiangming Li, Jing Huang, Akira Kawamura, Ryota Funakoshi, Steven A Porcelli, Moriya Tsuji

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Malaria vaccines: a new era of prevention and control.Nature reviews. Microbiology · 2024
    Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Xiangming LiAaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, New York, NY 10016, USA.
Jing HuangAaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, New York, NY 10016, USA.
Akira KawamuraDepartment of Chemistry, Hunter College of The City University of New York, New York, NY 10065, USA.
Ryota FunakoshiAaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, New York, NY 10016, USA.
Steven A PorcelliDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Moriya TsujiAaron Diamond AIDS Research Center, Affiliate of The Rockefeller University, New York, NY 10016, USA. Electronic address: mtsuji@adarc.org.
Aaron Diamond AIDS Research Center · USAlbert Einstein College of Medicine · USCity University of New York · US

Funding

CD1d/NKT-binding glycolipids in enhancing the immunogenicity of a malaria vaccineR01AI070258 · NIAID · AARON DIAMOND AIDS RESEARCH CENTER · PI TSUJI, MORIYA · 2012 to 2016
$2.2M
Mechanisms of induction of protective anti-malarial CD8+ T CellsR01AI102891 · NIAID · AARON DIAMOND AIDS RESEARCH CENTER · PI TSUJI, MORIYA · 2014 to 2017
$1.4M
CD1d/NKT-binding Glycolipids as an Adjuvant for a T cell-based Malaria VaccineR56AI070258 · NIAID · AARON DIAMOND AIDS RESEARCH CENTER · PI TSUJI, MORIYA · 2008 to 2009
$934k
NIAID NIH HHS R01 AI070258NIAID NIH HHS R01 AI102891NIAID NIH HHS R56 AI070258
6 · The paper itself

Abstract

A CD1d-binding, invariant (i) natural killer T (NKT)-cell stimulatory glycolipid, α-Galactosylceramide (αGalCer), has been shown to act as an adjuvant. We previously identified a fluorinated phenyl ring-modified αGalCer analog, 7DW8-5, displaying a higher binding affinity for CD1d molecule and more potent adjuvant activity than αGalCer. In the present study, 7DW8-5 co-administered intramuscularly (i.m.) with a recombinant adenovirus expressing a Plasmodium yoelii circumsporozoite protein (PyCSP), AdPyCS, has led to a co-localization of 7DW8-5 and a PyCSP in draining lymph nodes (dLNs), particularly in dendritic cells (DCs). This occurrence initiates a cascade of events, such as the recruitment of DCs to dLNs and their activation and maturation, and the enhancement of the ability of DCs to prime CD8+ T cells induced by AdPyCS and ultimately leading to a potent adjuvant effect and protection against malaria.

Indexed as

Adjuvants, ImmunologicAdenoviridaeAnimalsAntigens, CD1dAntigens, ProtozoanCD8-Positive T-LymphocytesDendritic CellsGalactosylceramidesImmunogenicity, VaccineInjections, IntramuscularInterferon-gammaKiller Cells, NaturalLymphocyte ActivationMalariaMalaria VaccinesMiceAdjuvants, Immunologicalpha-galactosylceramideAntigens, CD1dAntigens, ProtozoanGalactosylceramidesInterferon-gammaMalaria VaccinesVaccines, SyntheticAdenovirusCD1dCD8+ T cellsCo-localizationDendritic cellsGlycolipid adjuvantIntramuscular injectionLymph nodeMalaria vaccineProtection

Identifiers

PMID28483194
PMCPMC5489412
OpenAlexW2610166556

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.