ArticleArthritis research & therapy2017
Disturbed microcirculation in the hands of patients with systemic sclerosis detected by fluorescence optical imaging: a pilot study.
Article in Arthritis research & therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- To optimise the diagnostic process of rheumatic diseases affecting the hands using fluorescence optical imaging (FOI).RMD open · 2025Article
- Review
- Metabolic and molecular imaging in inflammatory arthritis.RMD open · 2024Review
- [Can rheuma be scanned? : Review of the current study situation on fluorescence optical imaging].Zeitschrift fur Rheumatologie · 2023Review
- Fluorescence optical imaging feature selection with machine learning for differential diagnosis of selected rheumatic diseases.Frontiers in medicine · 2023Article
- Features Found in Indocyanine Green-Based Fluorescence Optical Imaging of Inflammatory Diseases of the Hands.Diagnostics (Basel, Switzerland) · 2022Article
- Detection of microvascular changes in systemic sclerosis and other rheumatic diseases.Nature reviews. Rheumatology · 2021Review
- Fluorescence optical imaging: ready for prime time?RMD open · 2021Review
- Detection of subclinical skin manifestation in patients with psoriasis and psoriatic arthritis by fluorescence optical imaging.Arthritis research & therapy · 2020Article
- Novel Imaging Strategies in Systemic Sclerosis.Current rheumatology reports · 2020Review
- The first composite score predicting Digital Ulcers in systemic sclerosis patients using Clinical data, Imaging and Patient history-CIP-DUS.Arthritis research & therapy · 2020Article
- Cardiovascular optoacoustics: From mice to men - A review.Photoacoustics · 2019Review
- Association between baseline clinical and imaging findings and the development of digital ulcers in patients with systemic sclerosis.Arthritis research & therapy · 2019Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUtilising fluorescence optical imaging (FOI), the distribution of an intravenously applied colouring agent indocyanine green (ICG) can be analysed with the potential to identify malperfusion by little to no tissue enhancement. Systemic sclerosis (SSc) is characterised by the presence of digital ulcers reflecting progressive vasculopathy. The objective was to investigate the potential of FOI in the detection of disturbed microcirculation in the hands and fingers of patients with SSc and to link FOI findings to clinical signs of ischemia such as digital ulcers and pitting scars.
methodsIn this cross-sectional study, 63 patients with SSc and 26 healthy subjects were examined. FOI was performed in all 89 individuals and compared to clinical data and capillaroscopic findings assembled for the SSc cohort.
resultsHealthy subjects showed initial ICG signals in their fingertips in 93.6%, SSc patients in 78.5% (limited SSc) and 43.2% (diffuse SSc). Moreover, in SSc patients, FOI findings were significantly associated with a late capillaroscopic pattern, disseminated SSc features, a diffuse SSc subtype, and the presence of digital ulcers or pitting scars. Intra- and inter-reader reliability for FOI amounted to κ = 0.786 and κ = 0.834, respectively.
conclusionsFOI is able to detect areas of reduced microcirculation in patients with SSc with high association to capillaroscopic findings. The results pave the way for future FOI investigations into its role in the prediction of complications due to an impaired acral perfusion.
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