Evidence map›Paper›PMID 28482823›Full record

ArticleBMC nephrology2017

T-cells contribute to hypertension but not to renal injury in mice with subtotal nephrectomy.

Nynke R Oosterhuis, Diana A Papazova, Hendrik Gremmels, Jaap A Joles, Marianne C Verhaar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nynke R OosterhuisNephrology & Hypertension, University Medical Center Utrecht, PO Box 85500, 3508GA, Utrecht, Netherlands.
Diana A PapazovaNephrology & Hypertension, University Medical Center Utrecht, PO Box 85500, 3508GA, Utrecht, Netherlands.
Hendrik GremmelsNephrology & Hypertension, University Medical Center Utrecht, PO Box 85500, 3508GA, Utrecht, Netherlands.
Jaap A JolesNephrology & Hypertension, University Medical Center Utrecht, PO Box 85500, 3508GA, Utrecht, Netherlands.
Marianne C VerhaarNephrology & Hypertension, University Medical Center Utrecht, PO Box 85500, 3508GA, Utrecht, Netherlands. m.c.verhaar@umcutrecht.nl.
University Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe pathological condition of chronic kidney disease may not be adequately recapitulated in immunocompromised mice due to the lack of T-cells, which are important for the development of hypertension and renal injury. We studied the role of the immune system in relation to salt-sensitive hypertension and renal injury in mice with subtotal nephrectomy (SNX).

methodsWild-type immunocompetent (WT) and Foxn1

resultsHSD increased albumin excretion independent of immune status. Systolic blood pressure increased only in WT mice on HSD, not in AT mice. Uremia and morphological damage after SNX were not affected by either HSD or immune status.

conclusionsFor the development of hypertension after SNX in CD-1 mice mature T-cells and a high salt diet are required. SNX induced albuminuria was independent of the presence of T-cells.

Indexed as

Acute Kidney InjuryAnimalsHypertension, RenalMaleMiceMice, NudeNephrectomySodium Chloride, DietaryT-LymphocytesSodium Chloride, DietaryAlbuminuriaHigh salt dietHypertensionSubtotal nephrectomyT-cells

Identifiers

PMID28482823
PMCPMC5422945
OpenAlexW2613309367

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.