ReviewAnnual review of clinical psychology2017
Irritability in Children and Adolescents.
Review in Annual review of clinical psychology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06484088 (Characterizing the Brain Circuitry and Neural Activity Mediating Frustration), which is not on this map. Cited by 117 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Characterizing the Brain Circuitry and Neural Activity Mediating Frustration
Who cites it
117 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Understanding irritability through the lens of self-regulatory control processes in children and adolescents: a systematic review.European child & adolescent psychiatry · 2025Pooled it
- Annual Research Review: What processes are dysregulated among emotionally dysregulated youth? - a systematic review.Journal of child psychology and psychiatry, and allied disciplines · 2025Pooled it
- Irritability as a Transdiagnostic Construct Across Childhood and Adolescence: A Systematic Review and Meta-analysis.Clinical child and family psychology review · 2025Pooled it
- Predictors of irritability in pediatric autistic populations: a scoping review.Frontiers in child and adolescent psychiatry · 2024Pooled it
- Evidence Base Update on the Assessment of Irritability, Anger, and Aggression in Youth.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53Pooled it
- Trial
- The Effects of Emotion Regulation Treatment on Disruptive Behavior Problems in Children: A Randomized Controlled Trial.Research on child and adolescent psychopathology · 2022Trial
- Cross-Sectional Associations Among Symptoms of Pain, Irritability, and Depression and How These Symptoms Relate to Social Functioning and Quality of Life: Findings From the EMBARC and STRIDE Studies and the VitalSign6 Project.The Journal of clinical psychiatry · 2021Trial
- Association between irritability and suicidal ideation in three clinical trials of adults with major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- Differential antiseizure medication sensitivity of the Affective Reactivity Index: A randomized controlled trial in new-onset pediatric focal epilepsy.Epilepsy & behavior : E&B · 2020Trial
- Trial
- Bidirectional association between irritability and executive function in youth from late childhood to early adolescence: Between- and within-person effects.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026Article
- Article
- Associations of Tonic and Phasic Irritability With Psychopathology Subfactors of the Hierarchical Taxonomy of Psychopathology.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Evaluating anger in Chinese adolescents: Psychometric validation and clinical sensitivity of the Chinese version of the Children's Inventory of Anger.Pediatric investigation · 2026Article
- Youth Irritability as Consequence and Predictor of Family Conflict From Late Childhood to Early Adolescence.Child psychiatry and human development · 2026Article
- Reward processing in children with affective dysregulation.JCPP advances · 2026Article
- Towards treatments targeting the gut to improve behavioural outcomes in autism spectrum disorder.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Computer-based tree drawing test in adolescents and adults with depression.Frontiers in psychiatry · 2026Article
- Irritability in autism examined through network analysis of phenotypic and physiological correlates.Scientific reports · 2025Article
57 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Irritability is a common and impairing clinical presentation in children and adolescents. Despite its significant public health impact, irritability remains an elusive construct. Chronic and severe irritability is the primary symptom of the new DSM-5 diagnosis, disruptive mood dysregulation disorder (DMDD). However, empirical and clinical approaches to irritability are in their relative infancy, and questions regarding the validity of the DMDD diagnosis have been raised. Moreover, irritability is a trait distributed continuously in youth, thereby fitting within the National Institute of Mental Health Research Domain Criteria initiative. Thus, there are opportunities for scientific review and integration. Accordingly, the goals of this review include (a) clarifying the definitions of irritability, incorporating clinical and translational animal work; (b) reviewing the historical context surrounding the study of irritability;
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.