Evidence map›Paper›PMID 28482633›Full record

ArticleJournal of Alzheimer's disease : JAD2017

Amygdala α-Synuclein Pathology in the Population-Based Vantaa 85+ Study.

Anna Raunio, Liisa Myllykangas, Mia Kero, Tuomo Polvikoski, Anders Paetau, Minna Oinas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases.Journal of neuropathology and experimental neurology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anna RaunioDepartment of Pathology, University of Helsinkiand Helsinki University Hospital, Helsinki, Finland.
Liisa MyllykangasDepartment of Pathology, University of Helsinkiand Helsinki University Hospital, Helsinki, Finland.
Mia KeroDepartment of Pathology, University of Helsinkiand Helsinki University Hospital, Helsinki, Finland.
Tuomo PolvikoskiInstitute of Neuroscience, Newcastle University, Newcastle Upon Tyne, UK.
Anders PaetauDepartment of Pathology, University of Helsinkiand Helsinki University Hospital, Helsinki, Finland.
Minna OinasDepartment of Pathology, University of Helsinkiand Helsinki University Hospital, Helsinki, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the frequency of Lewy-related pathology (LRP) in the amygdala among the population-based Vantaa 85+ study. Data of amygdala samples (N = 304) immunostained with two α-synuclein antibodies (clone 42 and clone 5G4) was compared with the previously analyzed LRP and AD pathologies from other brain regions. The amygdala LRP was present in one third (33%) of subjects. Only 5% of pure AD subjects, but 85% of pure DLB subjects had LRP in the amygdala. The amygdala LRP was associated with dementia; however, the association was dependent on LRP on other brain regions, and thus was not an independent risk factor. The amygdala-predominant category was a rare (4%) and heterogeneous group.

Indexed as

Aged, 80 and overalpha-SynucleinAlzheimer DiseaseAmygdalaFemaleFinlandFollow-Up StudiesHumansLewy Body DiseaseLogistic ModelsMalePrevalencealpha-SynucleinSNCA protein, human80 and overagedAlzheimer’s diseaseamygdalaamygdala-predominantLewy body diseaseLewy-related pathologypopulation-based studyα-synuclein

Identifiers

PMID28482633
PMCPMC6218117

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.