ArticleProceedings of the National Academy of Sciences of the United States of America1988
Human DNA topoisomerase I is encoded by a single-copy gene that maps to chromosome region 20q12-13.2.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 92 citations in OpenAlex.
- Evolution of TOP1 and TOP1MT Topoisomerases in Chordata.Journal of molecular evolution · 2023Article
- Review
- Identification and characterization of a deletion mutant of DNA topoisomerase I mRNA in a camptothecin-resistant subline of human colon carcinoma.Japanese journal of cancer research : Gann · 2000Article
- DNA topoisomerase I in oncology: Dr Jekyll or Mr Hyde?Pathology oncology research : POR · 1999Review
- Review
- Topoisomerase I inhibitors and drug resistance.Cytotechnology · 1998Article
- CPT-11 sensitivity in relation to the expression of P170-glycoprotein and multidrug resistance-associated protein.British journal of cancer · 1998Article
- Topoisomerase I inhibitors: the relevance of prolonged exposure for present clinical development.British journal of cancer · 1997Review
- Variation in topoisomerase I gene copy number as a mechanism for intrinsic drug sensitivity.British journal of cancer · 1996Article
- Successful local regional therapy with topotecan of intraperitoneally growing human ovarian carcinoma xenografts.British journal of cancer · 1995Article
- Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Structure and function of type II DNA topoisomerases.The Biochemical journal · 1994Review
- The topoisomerase I gene from Ustilago maydis: sequence, disruption and mutant phenotype.Nucleic acids research · 1994Article
- Multilevel therapeutic targeting by topoisomerase inhibitors.The British journal of cancer. Supplement · 1994Review
- Fanconi anemia cells have a normal gene structure for topoisomerase I.Human genetics · 1994Article
- Genetic mapping of DNA topoisomerase I-related sequences to mouse chromosomes 2 and 14.Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
- Mouse genes encoding DNA topoisomerase I.Mammalian genome : official journal of the International Mammalian Genome Society · 1994Article
- Novel actions of inhibitors of DNA topoisomerase II in drug-resistant tumor cells.Cancer chemotherapy and pharmacology · 1994Review
- DNA topoisomerase I and II in cancer chemotherapy: update and perspectives.Cancer chemotherapy and pharmacology · 1993Review
- Cloning and Characterization of an Arabidopsis thaliana Topoisomerase I Gene.Plant physiology · 1992Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
cDNA clones of the human TOP1 gene encoding DNA topoisomerase I (EC 5.99.1.2) have been obtained by immunochemical screening of phage lambda libraries expressing human cDNA segments, using rabbit antibodies raised against purified HeLa DNA topoisomerase I. Hybridization patterns between the cloned cDNA sequences and human cellular DNA and cytoplasmic mRNAs indicate that human TOP1 is a single-copy gene. The chromosomal location of the gene has been mapped to the long arm of chromosome 20, in the region q12-13.2, by hybridization of a radioactively labeled TOP1 cDNA probe to human metaphase chromosomes and to a panel of rodent-human somatic hybrids retaining overlapping subsets of human chromosomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.