ArticleNeurobiology of aging2017
Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline.
Article in Neurobiology of aging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.
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Who cites it
72 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.
- Factors associated with brain ageing - a systematic review.BMC neurology · 2021Pooled it
- Article
- Investigating the Contribution of Molecular-Enriched Functional Connectivity to Brain-Age Analysis.Human brain mapping · 2026Article
- Article
- Neuroanatomical patterns of dementia risk in autism spectrum disorder.Frontiers in aging neuroscience · 2026Article
- Common pathogenic mechanisms in the hippocampus across neurodegenerative dementias: Alzheimer's disease, Down syndrome, and Parkinson's disease.NPJ dementia · 2026Article
- Distinct brain regions are affected by neurodevelopmental or pre-dementia changes in Down syndrome.Brain communications · 2026Article
- Investigating the Contribution of Molecular-Enriched Functional Connectivity to Brain-Age Analysis.bioRxiv : the preprint server for biology · 2025Article
- Neuroanatomical features reveal accelerated brain age in alcohol use disorder.bioRxiv : the preprint server for biology · 2025Article
- DoliClock: a lipid-based aging clock reveals accelerated aging in neurological disorders.Aging · 2025Article
- Network Occlusion Sensitivity Analysis Identifies Regional Contributions to Brain Age Prediction.Human brain mapping · 2025Article
- Validation of the CAMCOG-DS-II, a neuropsychological test battery for Alzheimer's disease in people with Down syndrome: A Horizon 21 European Down syndrome Consortium study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Adults with down syndrome exhibit altered somatosensory cortical inhibition.NeuroImage. Clinical · 2025Article
- Low-Rank Tensor Fusion for Enhanced Deep Learning-Based Multimodal Brain Age Estimation.Brain sciences · 2024Article
- On the Therapeutic Use of Monoclonal Antibodies Against Amyloid Plaques in Older Adults with Down Syndrome: A Narrative Review and Perspective.Brain sciences · 2024Review
- Does Employment Complexity Promote Healthy Cognitive Aging in Down Syndrome?Journal of intellectual disabilities : JOID · 2024Article
- Investigating the impact of motion in the scanner on brain age predictions.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Characterizing the emergence of amyloid and tau burden in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease.Molecular neurodegeneration · 2023Article
- Unraveling Down Syndrome: From Genetic Anomaly to Artificial Intelligence-Enhanced Diagnosis.Biomedicines · 2023Review
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
Individuals with Down syndrome (DS) are more likely to experience earlier onset of multiple facets of physiological aging. This includes brain atrophy, beta amyloid deposition, cognitive decline, and Alzheimer's disease-factors indicative of brain aging. Here, we employed a machine learning approach, using structural neuroimaging data to predict age (i.e., brain-predicted age) in people with DS (N = 46) and typically developing controls (N = 30). Chronological age was then subtracted from brain-predicted age to generate a brain-predicted age difference (brain-PAD) score. DS participants also underwent [
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.