Evidence map›Paper›PMID 28482157›Full record

ArticleACS chemical neuroscience2017

Enhancing Continuous Online Microdialysis Using Dexamethasone: Measurement of Dynamic Neurometabolic Changes during Spreading Depolarization.

Erika L Varner, Chi Leng Leong, Andrea Jaquins-Gerstl, Kathryn M Nesbitt, Martyn G Boutelle, Adrian C Michael

Abstract read
In one paragraph

Article in ACS chemical neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Article
  6. Review
  7. Dexamethasone-Enhanced Microdialysis and Penetration Injury.Frontiers in bioengineering and biotechnology · 2020
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Methods of Measuring Enzyme Activity Ex Vivo and In Vivo.Annual review of analytical chemistry (Palo Alto, Calif.) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Erika L VarnerDepartment of Chemistry, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.
Chi Leng LeongDepartment of Bioengineering, Imperial College London , London SW7 2AZ, United Kingdom.
Andrea Jaquins-GerstlDepartment of Chemistry, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.
Kathryn M NesbittDepartment of Chemistry, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.
Martyn G BoutelleDepartment of Bioengineering, Imperial College London , London SW7 2AZ, United Kingdom.
Adrian C MichaelDepartment of Chemistry, University of Pittsburgh , Pittsburgh, Pennsylvania 15260, United States.ORCID 0000-0001-9069-4664
University of Pittsburgh · USImperial College London · GB

Funding

Request for Zeiss 710 multiphoton 5Live Duoscan MicroscopeS10RR028478 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WATKINS, SIMON C · 2011 to 2011
$1.1M
Enhanced Microdialysis for CSD MonitoringR21NS092245 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MICHAEL, ADRIAN C · 2015 to 2016
$402k
NCRR NIH HHS S10 RR028478NINDS NIH HHS R21 NS092245
6 · The paper itself

Abstract

Microdialysis is well established in chemical neuroscience as a mainstay technology for real time intracranial chemical monitoring in both animal models and human patients. Evidence shows that microdialysis can be enhanced by mitigating the penetration injury caused during the insertion of microdialysis probes into brain tissue. Herein, we show that retrodialysis of dexamethasone in the rat cortex enhances the microdialysis detection of K

Indexed as

MicrodialysisAnimalsCerebral CortexCortical Spreading DepressionDexamethasoneGlucoseImmunohistochemistryMaleMicroscopy, FluorescenceNeuroprotective AgentsPotassiumRats, Sprague-DawleyTime FactorsDexamethasoneGlucoseNeuroprotective AgentsPotassiumbiosensordexamethasoneMicrodialysismicrofluidicspreading depolarization

Identifiers

PMID28482157
PMCPMC6677237
OpenAlexW2612587323

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.