ArticleJournal of the Pediatric Infectious Diseases Society2018
Epidemiology and Clinical Features of Human Coronaviruses in the Pediatric Population.
Article in Journal of the Pediatric Infectious Diseases Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- Intra-Household and Close-Contact SARS-CoV-2 Transmission Among Children - a Systematic Review.Frontiers in pediatrics · 2021Pooled it
- Arterial Thrombosis in Coronavirus Disease 2019 Patients: A Rapid Systematic Review.Annals of vascular surgery · 2021Pooled it
- Management strategies for children with COVID-19: ESPR practical recommendations.Pediatric radiology · 2020Guideline
- Shifting patterns of pediatric respiratory viruses during the SARS-CoV-2 pandemic: a retrospective observational study.BMC infectious diseases · 2026Observational
- Global Epidemiology and Seasonality of Human Seasonal Coronaviruses: A Systematic Review.Open forum infectious diseases · 2024Article
- Endemic Coronavirus Infections are Associated with Strong Homotypic Immunity in a US Cohort of Children from Birth to 4 Years.Journal of the Pediatric Infectious Diseases Society · 2024Article
- Impact of human coronavirus infections on paediatric patients at a tertiary paediatric hospital: a retrospective study of the prepandemic era.The Journal of hospital infection · 2023Article
- Detection of subgenomic mRNA from endemic human coronavirus OC43 and NL63 compared to viral genomic loads, single virus detection and clinical manifestations in children with respiratory tract infections.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2022Article
- Review
- SARS-CoV-2 and endemic coronaviruses: Comparing symptom presentation and severity of symptomatic illness among Nicaraguan children.medRxiv : the preprint server for health sciences · 2022Article
- SARS-CoV-2 and endemic coronaviruses: Comparing symptom presentation and severity of symptomatic illness among Nicaraguan children.PLOS global public health · 2022Article
- SARS-CoV-2 acute bronchiolitis in hospitalized children: Neither frequent nor more severe.Pediatric pulmonology · 2022Article
- Clinical Study of Human Coronavirus NL63, OC43, 229E, HKU1 Infentions in Hospitalized Children from 2015 to 2020.Infection and drug resistance · 2022Article
- The clinical and virological features of two children's coinfections with human adenovirus type 7 and human coronavirus-229E virus.Frontiers in public health · 2022Article
- Coronavirus seasonality, respiratory infections and weather.BMC infectious diseases · 2021Article
- Epidemiology and clinical features of common community human coronavirus disease.Journal of thoracic disease · 2021Article
- Risk Factors for Severity in Children with Coronavirus Disease 2019: A Comprehensive Literature Review.Pediatric clinics of North America · 2021Review
- COVID-19 and Pediatric Asthma: Clinical and Management Challenges.International journal of environmental research and public health · 2021Review
- Neutralizing and cross-reacting antibodies: implications for immunotherapy and SARS-CoV-2 vaccine development.Human vaccines & immunotherapeutics · 2021Review
- Virus strain from a mild COVID-19 patient in Hangzhou represents a new trend in SARS-CoV-2 evolution potentially related to Furin cleavage site.Emerging microbes & infections · 2020Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundThe epidemiology and clinical features of human coronaviruses (HCoVs) in children are not fully characterized.
methodsA retrospective study of children with HCoV detected by reverse-transcriptase polymerase chain reaction (RT-PCR) was performed for a community cohort and a children's hospital in the same community from January 2013 to December 2014. The RT-PCR assay detected HCoV 229E, HKU1, NL63, and OC43 in nasal swabs from symptomatic children ≤18 years. Factors associated with increased severity of illness in hospitalized children were assessed by multivariable logistic regression.
resultsHuman coronavirus was detected in 261 children, 49 and 212 from the community and hospital, respectively. The distribution of HCoV types and seasonal trends were similar in the community and hospital. Community cases were older than hospitalized cases (median age, 4.4 versus 1.7 years, respectively; P < .01), and a minority of community cases (26.5%) sought medical attention. Among the hospitalized children with HCoV detected, 39 (18.4%) received respiratory support and 24 (11.3%) were admitted to the pediatric intensive care unit (PICU). Age <2 years (odds ratio [OR] = 5.0; 95% confidence interval [CI], 1.9-13.1) and cardiovascular (OR = 3.9; 95% CI, 1.6-9.5), genetic/congenital (OR = 2.8; 95% CI, 1.1-7.0), and respiratory chronic complex conditions ([CCCs] OR = 4.5; 95% CI, 1.7-12.0) were associated with receiving respiratory support. Genetic/congenital (OR = 2.8; 95% CI, 1.1-7.4) CCCs were associated with PICU admission. Severity of illness was similar among hospitalized children with different HCoV types.
conclusionsChildren in the community with HCoV detected generally had mild illness as demonstrated by few medically attended cases. In hospitalized children, young age and CCCs, but not HCoV type, were associated with increased severity of illness.
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