Evidence map›Paper›PMID 28481991›Full record

ReviewBriefings in bioinformatics2018

Deep learning for healthcare: review, opportunities and challenges.

Riccardo Miotto, Fei Wang, Shuang Wang, Xiaoqian Jiang, Joel T Dudley

Abstract readReview
In one paragraph

Review in Briefings in bioinformatics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 719 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
719citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

719 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  6. AI in Medical Questionnaires: Scoping ReviewJournal of medical Internet research · 2025
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  10. Artificial intelligence in bronchoscopy: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
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659 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Riccardo MiottoInstitute for Next Generation Healthcare, Department of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai, New York, NY.
Fei WangDivision of Health Informatics, Department of Healthcare Policy and Research at Weill Cornell Medicine at Cornell University, New York, NY.
Shuang WangDepartment of Biomedical Informatics at the University of California San Diego, La Jolla, CA.
Xiaoqian JiangDepartment of Biomedical Informatics at the University of California San Diego, La Jolla, CA.
Joel T Dudleythe Institute for Next Generation Healthcare and associate professor in the Department of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai, New York, NY.

Funding

Mount Sinai Institutes for Clinical and Translational SciencesUL1TR000067 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SAMPSON, HUGH A · 2012 to 2014
$16.5M
Open Health Natural Language Processing CollaboratoryU01TR002062 · NCATS · MAYO CLINIC ROCHESTER · PI JIANG, XIAOQIAN, LIU, HONGFANG · 2017 to 2021
$7.6M
Decentralized differentially-private methods for dynamic data release and analysisR01GM118609 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JIANG, XIAOQIAN, OHNO-MACHADO, LUCILA · 2017 to 2020
$2.3M
User Interface PortalU54CA189201 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DUDLEY, JOEL THOMAS, MA'AYAN, AVI · 2014 to 2017
$1.9M
Methods for Evolutionary Informed Network Analysis to Discover Disease VariationR01DK098242 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DUDLEY, JOEL THOMAS · 2013 to 2016
$1.7M
Encryption methods and software for privacy-preserving analysis of biomedical dataU01EB023685 · NIBIB · TRUSTEES OF INDIANA UNIVERSITY · PI TANG, HAIXU, WANG, XIAOFENG · 2016 to 2018
$1.4M
SHARE: Statistical Health Information Release with Differential PrivacyR01GM114612 · NIGMS · EMORY UNIVERSITY · PI XIONG, LI · 2015 to 2017
$1.0M
Privacy preserving technologies for human genome data analysis and disseminationR01HG007078 · NHGRI · TRUSTEES OF INDIANA UNIVERSITY · PI TANG, HAIXU, WANG, XIAOFENG · 2013 to 2015
$886k
Protection of Records: Privacy (PReP) Technology for Medical ResearchR00LM011392 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JIANG, XIAOQIAN · 2013 to 2015
$650k
Protecting the pRivacy Of Genomes in REsearch StudieS (PROGRESS)R00HG008175 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WANG, SHUANG · 2016 to 2018
$527k
Protect Privacy of Healthcare Data in the CloudR21LM012060 · NLM · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JIANG, XIAOQIAN · 2014 to 2015
$376k
NCATS NIH HHS U01 TR002062NCATS NIH HHS UL1 TR000067NCI NIH HHS U54 CA189201NHGRI NIH HHS R00 HG008175NHGRI NIH HHS R01 HG007078NIBIB NIH HHS U01 EB023685NIDDK NIH HHS R01 DK098242NIGMS NIH HHS R01 GM114612NIGMS NIH HHS R01 GM118609NLM NIH HHS R00 LM011392NLM NIH HHS R21 LM012060
6 · The paper itself

Abstract

Gaining knowledge and actionable insights from complex, high-dimensional and heterogeneous biomedical data remains a key challenge in transforming health care. Various types of data have been emerging in modern biomedical research, including electronic health records, imaging, -omics, sensor data and text, which are complex, heterogeneous, poorly annotated and generally unstructured. Traditional data mining and statistical learning approaches typically need to first perform feature engineering to obtain effective and more robust features from those data, and then build prediction or clustering models on top of them. There are lots of challenges on both steps in a scenario of complicated data and lacking of sufficient domain knowledge. The latest advances in deep learning technologies provide new effective paradigms to obtain end-to-end learning models from complex data. In this article, we review the recent literature on applying deep learning technologies to advance the health care domain. Based on the analyzed work, we suggest that deep learning approaches could be the vehicle for translating big biomedical data into improved human health. However, we also note limitations and needs for improved methods development and applications, especially in terms of ease-of-understanding for domain experts and citizen scientists. We discuss such challenges and suggest developing holistic and meaningful interpretable architectures to bridge deep learning models and human interpretability.

Indexed as

Deep LearningComputational BiologyData MiningDelivery of Health CareDiagnostic ImagingElectronic Health RecordsGenomicsHumansTelemedicine

Identifiers

PMID28481991
PMCPMC6455466

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.