Evidence map›Paper›PMID 28481970›Full record

ArticleBioinformatics (Oxford, England)2017

Foldit Standalone: a video game-derived protein structure manipulation interface using Rosetta.

Robert Kleffner, Jeff Flatten, Andrew Leaver-Fay, David Baker, Justin B Siegel, Firas Khatib, Seth Cooper

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Article
  2. Optimal 1TEL-target protein linker character is target protein-dependent.Acta crystallographica. Section D, Structural biology · 2026
    Article
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  6. Review
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  11. High-throughput structure determination of an intrinsically disordered protein using cell-free protein crystallization.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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  19. Article
  20. Protein Structure Prediction with Mass Spectrometry Data.Annual review of physical chemistry · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Robert KleffnerCollege of Computer and Information Science, Northeastern University, Boston, MA 02115, USA.
Jeff FlattenDepartment of Computer Science and Engineering, University of Washington, Seattle, WA 98195, USA.
Andrew Leaver-FayDepartment of Biochemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
David BakerDepartment of Biochemistry.
Justin B SiegelGenome Center.
Firas KhatibDepartment of Computer and Information Science, University of Massachusetts Dartmouth, Dartmouth, MA 02747, USA.
Seth CooperCollege of Computer and Information Science, Northeastern University, Boston, MA 02115, USA.

Funding

Applying Protein Databases to Crowdsourcing Structural Protein DesignUH2CA203780 · NCI · NORTHEASTERN UNIVERSITY · PI COOPER, SETH EVERETT, KHATIB, FIRAS · 2016 to 2017
$620k
NCI NIH HHS UH2 CA203780
6 · The paper itself

Abstract

summaryFoldit Standalone is an interactive graphical interface to the Rosetta molecular modeling package. In contrast to most command-line or batch interactions with Rosetta, Foldit Standalone is designed to allow easy, real-time, direct manipulation of protein structures, while also giving access to the extensive power of Rosetta computations. Derived from the user interface of the scientific discovery game Foldit (itself based on Rosetta), Foldit Standalone has added more advanced features and removed the competitive game elements. Foldit Standalone was built from the ground up with a custom rendering and event engine, configurable visualizations and interactions driven by Rosetta. Foldit Standalone contains, among other features: electron density and contact map visualizations, multiple sequence alignment tools for template-based modeling, rigid body transformation controls, RosettaScripts support and an embedded Lua interpreter. AVAILABILITY AND IMPLEMENTATION: Foldit Standalone is available for download at https://fold.it/standalone , under the Rosetta license, which is free for academic and non-profit users. It is implemented in cross-platform C ++ and binary executables are available for Windows, macOS and Linux. CONTACT: scooper@ccs.neu.edu.

Indexed as

Models, MolecularProtein ConformationSoftwareComputational BiologySequence AlignmentSequence Analysis, ProteinVideo Games

Identifiers

PMID28481970
PMCPMC5860063

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.