ArticlePloS one2017
The role of VosA/VelB-activated developmental gene vadA in Aspergillus nidulans.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 36 citations in OpenAlex.
- The VelB IDD promotes selective heterodimer formation of velvet proteins for fungal development.Life science alliance · 2026Article
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- HSP104 and HSP20-L Are Required by Aspergillus nidulans in Response to Attack by Fungivorous Springtail Sinella curviseta.Environmental microbiology reports · 2025Article
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- The Forkhead GeneJournal of microbiology and biotechnology · 2023Article
- Regulators of the Asexual Life Cycle ofCells · 2023Review
- srdA mutations suppress the rseA/cpsA deletion mutant conidiation defect in Aspergillus nidulans.Scientific reports · 2023Article
- The Putative CCells · 2022Article
- The function of a conidia specific transcription factor CsgA in Aspergillus nidulans.Scientific reports · 2022Article
- The putative sensor histidine kinase VadJ coordinates development and sterigmatocystin production in Aspergillus nidulans.Journal of microbiology (Seoul, Korea) · 2021Article
- Functions of PUF Family RNA-Binding Proteins inJournal of microbiology and biotechnology · 2021Article
- Article
- HbxB Is a Key Regulator for Stress Response and β-Glucan Biogenesis inMicroorganisms · 2021Article
- Unveiling the Functions of the VosA-VelB Target GeneMycobiology · 2021Article
- Velvet activated McrA plays a key role in cellular and metabolic development in Aspergillus nidulans.Scientific reports · 2020Article
- TheInternational journal of molecular sciences · 2020Article
- Genome Wide Analysis Reveals the Role of VadA in Stress Response, Germination, and Sterigmatocystin Production inMicroorganisms · 2020Article
- The role of the VosA-repressed dnjA gene in development and metabolism in Aspergillus species.Current genetics · 2020Article
- Homeobox proteins are essential for fungal differentiation and secondary metabolism in Aspergillus nidulans.Scientific reports · 2020Article
- Characterizing the role of Zn cluster family transcription factor ZcfA in governing development in two Aspergillus species.PloS one · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The filamentous fungus Aspergillus nidulans primarily reproduces by forming asexual spores called conidia, the integrity of which is governed by the NF-κB type velvet regulators VosA and VelB. The VosA-VelB hetero-complex regulates the expression of spore-specific structural and regulatory genes during conidiogenesis. Here, we characterize one of the VosA/VelB-activated developmental genes, called vadA, the expression of which in conidia requires activity of both VosA and VelB. VadA (AN5709) is predicted to be a 532-amino acid length fungal-specific protein with a highly conserved domain of unknown function (DUF) at the N-terminus. This DUF was found to be conserved in many Ascomycota and some Glomeromycota species, suggesting a potential evolutionarily conserved function of this domain in fungi. Deletion studies of vadA indicate that VadA is required for proper downregulation of brlA, fksA, and rodA, and for proper expression of tpsA and orlA during sporogenesis. Moreover, vadA null mutant conidia exhibit decreased trehalose content, but increased β(1,3)-glucan levels, lower viability, and reduced tolerance to oxidative stress. We further demonstrate that the vadA null mutant shows increased production of the mycotoxin sterigmatocystin. In summary, VadA is a dual-function novel regulator that controls development and secondary metabolism, and participates in bridging differentiation and viability of newly formed conidia in A. nidulans.
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