ArticleJournal of dental research2017
Contribution of the PDL to Osteotomy Repair and Implant Osseointegration.
Article in Journal of dental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- [Clinical efficacy of demineralized dentin matrix particles in immediate implantation for bone defects in posterior region: a 1 to 5-year follow-up study].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025Article
- MicroRNA functions in osteogenic differentiation of periodontal ligament stem cells: a scoping review.Frontiers in oral health · 2025Review
- Effects of surface nanomorphology on the senescence of periodontal ligament stem cells.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2024Article
- Review
- Subset of the periodontal ligament expressed leptin receptor contributes to part of hard tissue-forming cells.Scientific reports · 2023Article
- Bone Sialoprotein Is Critical for Alveolar Bone Healing in Mice.Journal of dental research · 2023Article
- Titanium Nanosurface with a Biomimetic Physical Microenvironment to Induce Endogenous Regeneration of the Periodontium.ACS applied materials & interfaces · 2022Article
- Alveolar Bone Marrow Gli1+ Stem Cells Support Implant Osseointegration.Journal of dental research · 2022Article
- Comparison of extraction sites versus artificial defects with xenogenic bone substitute in minipigs.Clinical and experimental dental research · 2021Article
- Comparative analyses of the soft tissue interfaces around teeth and implants: Insights from a pre-clinical implant model.Journal of clinical periodontology · 2021Article
- Pro-osteogenic Effects of WNT in a Mouse Model of Bone Formation Around Femoral Implants.Calcified tissue international · 2021Article
- Caspase inhibitor attenuates the shape changes in the alveolar ridge following tooth extraction: A pilot study in rats.Journal of periodontal research · 2021Article
- Optimizing autologous bone contribution to implant osseointegration.Journal of periodontology · 2020Article
- Role of Hippo-YAP Signaling in Osseointegration by Regulating Osteogenesis, Angiogenesis, and Osteoimmunology.Frontiers in cell and developmental biology · 2020Review
- Mechanical and Biological Advantages of a Tri-Oval Implant Design.Journal of clinical medicine · 2019Article
- A Novel Osteotomy Preparation Technique to Preserve Implant Site Viability and Enhance Osteogenesis.Journal of clinical medicine · 2019Article
- Biomechanics of Immediate Postextraction Implant Osseointegration.Journal of dental research · 2018Article
- A Wnt-Responsive PDL Population Effectuates Extraction Socket Healing.Journal of dental research · 2018Article
- A Comparative Assessment of Implant Site Viability in Humans and Rats.Journal of dental research · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
Our objective was to clarify the fate of the periodontal ligament (PDL) retained in the socket after tooth extraction, then determine if this tissue contributed to the osseointegration of "immediate" implants placed in these fresh extraction sockets. Mice underwent maxillary first molar extraction, the residual PDL was removed by an osteotomy, and titanium implants were placed. The osteotomy was created in such a way that the palatal surface was devoid of PDL remnants while the buccal, mesial, and distal surfaces retained PDL fibers. At multiple time points after surgery, tissues were analyzed using a battery of molecular, cellular, and histomorphometrical assays. We found that PDL remnants mineralized and directly contributed to new bone formation in the extraction site. Compared with regions of an extraction site where the PDL was removed by osteotomy, regions that retained PDL fibers had produced significantly more new bone. Around immediate implants, the retained PDL remnants directly contributed to new bone formation and osseointegration. Thus, we conclude that PDL remnants are inherently osteogenic, and if the tissue is healthy, it is reasonable to conclude that curetting out an extraction socket prior to immediate implant placement should be avoided. This recommendation aligns with contemporary trends toward minimally invasive surgical manipulations of the extraction socket prior to immediate implant placement.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.