ArticleAmerican journal of respiratory and critical care medicine2017
Computed Tomography Measure of Lung at Risk and Lung Function Decline in Chronic Obstructive Pulmonary Disease.
Article in American journal of respiratory and critical care medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00608764 (Genetic Epidemiology of Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene)
Who cites it
49 citing papers in PubMed.
- Chest CT imaging toward personalized management of chronic obstructive pulmonary disease, asthma, and bronchiectasis: pulmonologist perspectives.Japanese journal of radiology · 2026Review
- Imaging in Chronic Obstructive Pulmonary Disease: Ready for Prime Time?Tuberculosis and respiratory diseases · 2026Article
- Pulmonary Biomechanics in COPD: Imaging Techniques and Clinical Applications.Journal of biomechanical engineering · 2025Review
- Bridging the Gap: Small Airways, Mechanical Stress, and the Evolution of Emphysema.American journal of respiratory and critical care medicine · 2025Article
- Mechanically Affected Lung and Progression of Emphysema.American journal of respiratory and critical care medicine · 2025Article
- Resistive breathing aggravates cigarette smoke-induced pulmonary inflammation.ERJ open research · 2025Article
- Do You Believe in Magic? Computed Tomography, Artificial Intelligence, and Chronic Obstructive Pulmonary Disease.American journal of respiratory and critical care medicine · 2025Article
- Automated CT-based measurements of radial and longitudinal expansion of airways due to breathing-related lung volume change.Medical physics · 2025Article
- 4DCT image artifact detection using deep learning.Medical physics · 2025Article
- Investigating the impact of kernel harmonization and deformable registration on inspiratory and expiratory chest CT images for people with COPD.Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- Computed Tomography Radiomics Features Predict Change in Lung Density and Rate of Emphysema Progression.Annals of the American Thoracic Society · 2025Article
- Benefit of dual bronchodilator therapy on exacerbations in former and current smokers with chronic obstructive pulmonary disease in real-world clinical practice: a multicenter validation study (TOReTO).Respiratory research · 2024Article
- CT strain metrics allow for earlier diagnosis of bronchiolitis obliterans syndrome after hematopoietic cell transplant.Blood advances · 2024Article
- Local heterogeneity of normal lung parenchyma and small airways disease are associated with COPD severity and progression.Respiratory research · 2024Article
- SPECT/CT to quantify early small airway disease and its relationship to clinical symptoms in smokers with normal lung function: a pilot study.Frontiers in physiology · 2024Article
- Quantitative CT of Normal Lung Parenchyma and Small Airways Disease Topologies are Associated With COPD Severity and Progression.medRxiv : the preprint server for health sciences · 2023Article
- FEVAmerican journal of respiratory and critical care medicine · 2023Article
- Lung functional imaging.Breathe (Sheffield, England) · 2023Article
- Human Immunodeficiency Virus-associated Chronic Obstructive Pulmonary Disease Is Characterized by Increased Small Airways Dysfunction on Computed Tomography Imaging.Annals of the American Thoracic Society · 2023Article
- Acute Exacerbations Are Associated with Progression of Emphysema.Annals of the American Thoracic Society · 2022Article
Corrections and comments
- Commented on by
Authors and funding
8 authors.
Funding
Abstract
rationaleThe rate of decline of lung function is greater than age-related change in a substantial proportion of patients with chronic obstructive pulmonary disease, even after smoking cessation. Regions of the lung adjacent to emphysematous areas are subject to abnormal stretch during respiration, and this biomechanical stress likely influences emphysema initiation and progression.
objectivesTo assess whether quantifying this penumbra of lung at risk would predict FEV
methodsWe analyzed paired inspiratory-expiratory computed tomography images at baseline of 680 subjects participating in a large multicenter study (COPDGene) over approximately 5 years. By matching inspiratory and expiratory images voxel by voxel using image registration, we calculated the Jacobian determinant, a measure of local lung expansion and contraction with respiration. We measured the distance between each normal voxel to the nearest emphysematous voxel, and quantified the percentage of normal voxels within each millimeter distance from emphysematous voxels as mechanically affected lung (MAL). Multivariable regression analyses were performed to assess the relationship between the Jacobian determinant, MAL, and FEV MEASUREMENTS AND MAIN
resultsThe mean (SD) rate of decline in FEV
conclusionsAreas of normal-appearing lung are mechanically influenced by emphysematous areas and this lung at risk is associated with lung function decline. Clinical trial registered with www.clinicaltrials.gov (NCT00608764).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.