Evidence map›Paper›PMID 28481415›Full record

ArticleThe Journal of physiology2017

Large-conductance Ca

Nathan A Zaidman, Angela Panoskaltsis-Mortari, Scott M O'Grady

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Potassium Channels of the Airway Epithelium.Acta physiologica (Oxford, England) · 2026
    Review
  2. Article
  3. Allergen-induced activation of epithelial P2YThe Journal of allergy and clinical immunology · 2025
    Article
  4. Article
  5. Article
  6. Oxidative stress, autophagy and airway ion transport.American journal of physiology. Cell physiology · 2019
    Review
  7. Exocrine secretion spelled with a capital KThe Journal of physiology · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nathan A ZaidmanDepartment of Integrative Biology and Physiology, University of Minnesota, 6-125 Jackson Hall, Minneapolis, MN, USA.
Angela Panoskaltsis-MortariDepartment of Integrative Biology and Physiology, University of Minnesota, 6-125 Jackson Hall, Minneapolis, MN, USA.
Scott M O'GradyDepartment of Integrative Biology and Physiology, University of Minnesota, 6-125 Jackson Hall, Minneapolis, MN, USA.ORCID 0000-0002-0474-5451
University of Minnesota · US

Funding

Overcoming Barriers to Bioengineering 3-D Human LungR01HL108627 · NHLBI · UNIVERSITY OF MINNESOTA · PI PANOSKALTSIS-MORTARI, ANGELA, TAYLOR, DORIS A · 2011 to 2014
$3.0M
Allergen-induced IL-33 release by the airway epitheliumR01HL110539 · NHLBI · MAYO CLINIC ROCHESTER · PI KITA, HIROHITO, O'GRADY, SCOTT M. · 2011 to 2014
$2.0M
Engineering human iPS cells into an airway epithelium capable of ion transportF31EB018707 · NIBIB · UNIVERSITY OF MINNESOTA · PI ZAIDMAN, NATHAN A · 2014 to 2015
$58k
NHLBI NIH HHS R01 HL108627NHLBI NIH HHS R01 HL110539NIBIB NIH HHS F31 EB018707
6 · The paper itself

Abstract

key pointsHydrocortisone (HC) is required for activation of large-conductance Ca ABSTRACT: In the present study we investigated the role of hydrocortisone (HC) on uridine-5'-triphosphate (UTP)-stimulated ion transport in differentiated, pseudostratified epithelia derived from normal human bronchial basal cells. The presence of a UTP-stimulated, paxilline-sensitive large-conductance Ca

Indexed as

Adenosine TriphosphateBronchiCell DifferentiationCell LineEpithelial CellsHumansHydrocortisoneIndolesLarge-Conductance Calcium-Activated Potassium ChannelsMaleimidesPotassium Channel BlockersProtein Kinase CProtein Kinase InhibitorsPurinergic P2Y Receptor AgonistsReceptors, Purinergic P2YRespiratory Mucosa2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimideAdenosine Triphosphatebisindolylmaleimide IHydrocortisoneIndolesLarge-Conductance Calcium-Activated Potassium ChannelsMaleimidespaxillinePotassium Channel BlockersProtein Kinase CProtein Kinase InhibitorsPurinergic P2Y Receptor AgonistsReceptors, Purinergic P2YUridine Triphosphatecalcium-activated potassium channelcystic fibrosis transmembrane conductance regulator (CFTR)epithelial ion transportepithelial sodium channel (ENaC)glucocorticoidP2Y receptor

Identifiers

PMID28481415
PMCPMC5509885
OpenAlexW2613342156

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.