ArticleNature medicine2017
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
Erratum issued 4 registry-linked trialsAbstract read
In one paragraph
Article in Nature medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 4 registered trials, which are not on this map. Cited by 2,163 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
2,163citing papers in PubMed, 4 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cabozantinib Plus Durvalumab in Patients With Advanced and Chemotherapy-treated Bladder Carcinoma, of Urothelial and Non-urothelial Histology: an Open-label, Single-centre, Phase 2, Single-arm Proof-of-concept Trial: ARCADIA Study
A Clinical Trial to Evaluate the Efficacy, Safety, and Tolerability of Arsenic Trioxide for Injection in Patients With Recurrent and Metastatic Ovarian Cancer and Endometrial Cancer With P53 Mutation
Tempus Priority Study: An Observational Study of Patients Who Have Received Comprehensive Genomic Profiling
A Phase II Trial of Neural Network-based Treatment Decision Support Tool in Patients With Refractory Solid Organ Malignancies
Who cites it
2,163 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- A meta-analysis identifies driver genes and characterizes the molecular epidemiology of colorectal cancer.Scientific reports · 2026Pooled it
- EMQN best practice guidelines for analysis and reporting of microsatellite instability in solid tumours.European journal of human genetics : EJHG · 2026Guideline
- Meta-analysis reveals differences in somatic alterations by genetic ancestry across common cancers.Nature genetics · 2025Pooled it
- Somatic mutations in Middle East and North Africa breast cancer patients: a systematic review.The oncologist · 2025Pooled it
- Very low-carbohydrate ketogenic diet in treatment-naïve women with endometrial cancer and overweight: a randomized feasibility study.Nature communications · 2026Trial
- Phase 2 study of palbociclib plus retifanlimab in patients with advanced dedifferentiated liposarcoma.Journal for immunotherapy of cancer · 2026Trial
- Phase 2 Study of Amivantamab Plus Lazertinib in Previously Treated Patients With EGFR-Mutant Lung Cancers With Brain and Leptomeningeal Metastases.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026Trial
- Cancer metastasis: biological mechanisms, therapeutic bottlenecks, and emerging interventions.Journal of hematology & oncology · 2026Review
- Co-mutation patterns and survival associations in lung cancer: a comparative analysis of Swedish and global cohorts.Acta oncologica (Stockholm, Sweden) · 2026Article
- Genomic Medicine Sweden: Advancing precision medicine at the national level.Journal of internal medicine · 2026Review
- Preclinical Characterization of CLSP-1025, a First-in-Class, Mutation-Specific T-Cell Engager Targeting a Neoantigen Derived from a Common p53 Mutation.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- Workforce and institutional factors associated with comprehensive genomic profiling utilization in gynecologic oncology: a nationwide questionnaire survey in Japan.International journal of clinical oncology · 2026Article
- Clinical metastatic cancer from initiation to colonization: emerging challenges and breakthroughs.Oncogene · 2026Review
- Integrated Structural and Dynamic Analysis Reveals Destabilizing Effects of KRAS Missense Variants Associated with Lung Cancer.The protein journal · 2026Article
- Molecular and Clinical Determinants of Targeted Therapy Treatment in Biliary Tract Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026Article
- Integrated clinicogenomic analysis reveals the evolution and metastatic tropisms of advanced colorectal cancer.Cancer cell · 2026Article
- Antagonistic roles of histone H3 lysine methyltransferases dictate tumor immune surveillance.Nature communications · 2026Article
- Uncommon location, diagnostic challenge: A case series of acral low-grade fibromyxoid sarcoma.Virchows Archiv : an international journal of pathology · 2026Article
- Chinese expert consensus on precision testing and molecular diagnosis of pancreatic cancer (2025).British journal of cancer · 2026Article
- Sequencing approaches in hereditary cancer testing: strengths, limitations and future directions.European journal of human genetics : EJHG · 2026Review
2,103 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
100 authors.
Ahmet ZehirDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID http://orcid.org/0000-0001-5406-4104
Ryma BenayedDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Ronak H ShahDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Aijazuddin SyedDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Sumit MiddhaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID http://orcid.org/0000-0003-4135-6268
Hyunjae R KimDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID http://orcid.org/0000-0002-1869-0412
Preethi SrinivasanDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Jianjiong GaoMarie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Debyani ChakravartyMarie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Sean M DevlinDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Matthew D HellmannDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
David A BarronDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Alison M SchramDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Meera HameedDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Snjezana DoganDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Dara S RossDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Jaclyn F HechtmanDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Deborah F DeLairDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
JinJuan YaoDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Diana L MandelkerDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Donavan T ChengDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Raghu ChandramohanDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Abhinita S MohantyDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Ryan N PtashkinDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Gowtham JayakumaranDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Meera PrasadDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Mustafa H SyedDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Anoop Balakrishnan RemaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID http://orcid.org/0000-0001-6104-5665
Zhen Y LiuDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Khedoudja NafaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Laetitia BorsuDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Justyna SadowskaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Jacklyn CasanovaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID http://orcid.org/0000-0002-3586-7048
Ruben BacaresDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Iwona J KieckaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Anna RazumovaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Julie B SonDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Lisa StewartDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Tessara BaldiDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Kerry A MullaneyDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Hikmat Al-AhmadieDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Efsevia VakianiDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Adam A AbeshouseDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Alexander V PensonDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Philip JonssonDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Niedzica CamachoDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Matthew T ChangDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Helen H WonDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Benjamin E GrossMarie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Ritika KundraMarie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Zachary J HeinsMarie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Hsiao-Wei ChenMarie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Sarah PhillipsMarie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Hongxin ZhangMarie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Jiaojiao WangMarie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Angelica OchoaMarie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Jonathan WillsInformation Systems, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Michael EubankInformation Systems, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Stacy B ThomasInformation Systems, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID http://orcid.org/0000-0003-3306-5655
Stuart M GardosInformation Systems, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Dalicia N RealesClinical Research Administration, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Jesse GalleClinical Research Administration, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Robert DuranyClinical Research Administration, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Roy CambriaClinical Research Administration, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Wassim AbidaDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Andrea CercekDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Darren R FeldmanDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Mrinal M GounderDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
A Ari HakimiDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
James J HardingDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Gopa IyerDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID http://orcid.org/0000-0002-5093-6099
Yelena Y JanjigianDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Emmet J JordanDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Ciara M KellyDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Maeve A LoweryDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Luc G T MorrisDepartment of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Antonio M OmuroDepartment of Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Nitya RajDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Pedram RazaviDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Alexander N ShoushtariDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID http://orcid.org/0000-0002-8065-4412
Neerav ShuklaDepartment of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Tara E SoumeraiDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Anna M VargheseDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Rona YaegerDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Jonathan ColemanClinical Research Administration, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Bernard BochnerClinical Research Administration, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Gregory J RielyDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Leonard B SaltzDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Howard I ScherDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Paul J SabbatiniDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Mark E RobsonDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
David S KlimstraDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Barry S TaylorMarie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Jose BaselgaDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Nikolaus SchultzMarie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
David M HymanDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Maria E ArcilaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
David B SolitMarie-Josée and Henry R. Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Marc LadanyiDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Michael F BergerDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MSPORE In Prostate CancerP50CA092629 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Yu Chen, MICHAEL J MORRIS · 2001 to 2026
$63.0MThe Role of Focal Oncogene Amplifications in Lung CancerP01CA129243 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Andrea Ventura · 2007 to 2026
$31.2MInvestigational Cancer Therapeutics Training Program (ICTTP)T32CA009207 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Omar Abdel-Wahab, Alexander Drilon · 1985 to 2026
$13.7MUnderstanding Long Tail Driver Mutations in CancerR01CA204749 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI SCHULTZ, NIKOLAUS · 2017 to 2021
$2.0MDefining the temporal sequence of PI3K pathway mutations in bladder cancerR01CA182587 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI SOLIT, DAVID B. · 2014 to 2018
$1.8MFunctionalizing recurrent FAT1 mutations and deletions in oral cancerK08DE024774 · NIDCR · SLOAN-KETTERING INST CAN RESEARCH · PI MORRIS, LUC GORDON TRANG · 2014 to 2018
$682kNCI NIH HHS P01 CA129243NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA092629NCI NIH HHS R01 CA182587NCI NIH HHS R01 CA204749NIDCR NIH HHS K08 DE024774
Abstract
Tumor molecular profiling is a fundamental component of precision oncology, enabling the identification of genomic alterations in genes and pathways that can be targeted therapeutically. The existence of recurrent targetable alterations across distinct histologically defined tumor types, coupled with an expanding portfolio of molecularly targeted therapies, demands flexible and comprehensive approaches to profile clinically relevant genes across the full spectrum of cancers. We established a large-scale, prospective clinical sequencing initiative using a comprehensive assay, MSK-IMPACT, through which we have compiled tumor and matched normal sequence data from a unique cohort of more than 10,000 patients with advanced cancer and available pathological and clinical annotations. Using these data, we identified clinically relevant somatic mutations, novel noncoding alterations, and mutational signatures that were shared by common and rare tumor types. Patients were enrolled on genomically matched clinical trials at a rate of 11%. To enable discovery of novel biomarkers and deeper investigation into rare alterations and tumor types, all results are publicly accessible.
Indexed as
Biomarkers, TumorCohort StudiesData MiningDNA, NeoplasmFeasibility StudiesFemaleGenomicsHigh-Throughput Nucleotide SequencingHumansMaleMutationNeoplasm MetastasisNeoplasmsProspective StudiesSequence Analysis, DNABiomarkers, TumorDNA, Neoplasm
Identifiers
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Registered trials
NCT03824691ClinicalTrials.gov
NCT04489706ClinicalTrials.gov
NCT05179824ClinicalTrials.gov
NCT05719428ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.