ArticleNutrition & diabetes2017
Association between individual fat depots and cardio-metabolic traits in normal- and overweight children, adolescents and adults.
Article in Nutrition & diabetes, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Sex as a moderator of body composition following a randomized controlled lifestyle intervention among Latino youth with obesity.Pediatric obesity · 2020Trial
- Determinants of bone mass in older adults with normal- and overweight derived from the crosstalk with muscle and adipose tissue.Scientific reports · 2023Article
- Analysis of the adiponectin paradox in healthy older people.Journal of cachexia, sarcopenia and muscle · 2023Article
- Magnetic Resonance Imaging to Assess Body Composition Change in Adolescents With Obesity After Sleeve Gastrectomy.Journal of pediatric gastroenterology and nutrition · 2022Article
- A Multivariate Analysis of "Metabolic Phenotype" Patterns in Children and Adolescents with Obesity for the Early Stratification of Patients at Risk of Metabolic Syndrome.Journal of clinical medicine · 2022Article
- Bone marrow adipose tissue content in Latino adolescents with prediabetes and obesity.Obesity (Silver Spring, Md.) · 2021Article
- Changes in adiposity among children and adolescents in the United States, 1999-2006 to 2011-2018.The American journal of clinical nutrition · 2021Article
- Effect of fat mass index, fat free mass index and body mass index on childhood blood pressure: a cross-sectional study in south China.Translational pediatrics · 2021Article
- Prematurity With Extrauterine Growth Restriction Increases the Risk of Higher Levels of Glucose, Low-Grade of Inflammation and Hypertension in Prepubertal Children.Frontiers in pediatrics · 2020Article
- Reaching the Tipping Point: Identification of Thresholds at which Visceral Adipose Tissue May Steeply Increase in Youth.Obesity (Silver Spring, Md.) · 2020Article
- Changes in overall and regional body fatness from childhood to early adolescence.Scientific reports · 2019Article
- Greater Reduction in Abdominal Than in Upper Arms Subcutaneous Fat in 10- to 12-Year-Old Tennis Players: A Volumetric MRI Study.Frontiers in pediatrics · 2019Article
- MiR-27b-3p Inhibition Enhances Browning of Epididymal Fat in High-Fat Diet Induced Obese Mice.Frontiers in endocrinology · 2019Article
- Body composition and insulin resistance in children.European journal of clinical nutrition · 2018Review
- Associations of adult genetic risk scores for adiposity with childhood abdominal, liver and pericardial fat assessed by magnetic resonance imaging.International journal of obesity (2005) · 2018Article
- Definition of new cut-offs of BMI and waist circumference based on body composition and insulin resistance: differences between children, adolescents and adults.Obesity science & practice · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine age-related associations between fat mass (FM), regional fat depots and cardiometabolic traits in normal- and overweight children, adolescents and adults.
methodsDetailed body composition (regional subcutaneous and visceral adipose tissue; SAT, VAT) by whole-body magnetic resonance imaging (MRI), FM and fat-free mass by air-displacement plethysmography, systolic and diastolic blood pressure (SBP, DBP), triglycerides (TG), high-density lipoprotein cholesterol (HDL), plasma glucose and plasma insulin were measured in 433 subjects (BMI: 23.6 (21.0-27.7); 151 children and adolescents, aged 6-18 years, 150 young adults, aged 18-30 years and 132 adults, aged 30-60 years). Data were derived from pooled data of the 'Reference Center for Body Composition' in Kiel, Germany. Insulin resistance was determined by the homeostatic model assessment of insulin resistance (HOMA-IR). Partial correlations and multivariate linear regression analyses were used to evaluate the associations between body composition and cardiometabolic traits. A descriptive approach was used to demonstrate age-dependent differences in associations between body fat depots and insulin resistance, independent of BMI.
resultsFM, SAT, and VAT increased from childhood to adulthood with low VAT in children and adolescents. When compared to children, TG was higher in adults. HDL and DBP did not differ between age groups. Insulin resistance was highest in male adolescents and female young adults. Associations between body fat depots and cardiometabolic traits were seen after puberty with no associations in pre- and intrapubertal children. When compared to FM, SAT and VAT had the strongest association with insulin resistance in adults. This association was independent of BMI.
conclusionsAssociations between individual body fat depots and most cardiometabolic traits became evident after puberty only. The strongest associations were observed between insulin resistance and abdominal fat in adults. The impact of VAT was independent of BMI.
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