Evidence map›Paper›PMID 28481323›Full record

ArticleMolecules (Basel, Switzerland)2017

Ionic Liquid as an Efficient Medium for the Synthesis of Quinoline Derivatives via α-Chymotrypsin-Catalyzed Friedländer Condensation.

Zhang-Gao Le, Meng Liang, Zhong-Sheng Chen, Sui-Hong Zhang, Zong-Bo Xie

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Fast quinazolinone synthesis by combining enzymatic catalysis and photocatalysis.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zhang-Gao LeJiangxi 2011 Joint Center for the Innovative Mass Spectrometry and Instrumentation, East China University of Technology, Nanchang 330013, China. zhgle@ecit.cn.
Meng LiangSchool of Chemistry, Biology and Material Science, East China University of Technology, Nanchang 330013, China. 13247718220@163.com.
Zhong-Sheng ChenSchool of Chemistry, Biology and Material Science, East China University of Technology, Nanchang 330013, China. zhshcheng@ecit.cn.
Sui-Hong ZhangSchool of Chemistry, Biology and Material Science, East China University of Technology, Nanchang 330013, China. zsh18170400156@163.com.
Zong-Bo XieJiangxi 2011 Joint Center for the Innovative Mass Spectrometry and Instrumentation, East China University of Technology, Nanchang 330013, China. zbxie@ecit.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An efficient, convenient, and eco-friendly biocatalytic approach was developed for the synthesis of quinoline derivatives via the α-chymotrypsin-catalyzed Friedländer reaction. Interestingly, α-chymotrypsin exhibited higher catalytic activity in an ionic liquid (IL) aqueous solution as compared to that observed in our previous relevant study, which was conducted using an organic solvent, and a series of substrates gave similar excellent yields at lower reaction temperature and under reduced enzyme-loading conditions.

Indexed as

CatalysisChymotrypsinIonic LiquidsQuinolinesalpha-chymotrypsinChymotrypsinIonic LiquidsQuinolinesbiocatalysisFriedländer reactionionic liquidpromiscuityquinolinesα-chymotrypsin

Identifiers

PMID28481323
PMCPMC6154722

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.