Evidence map›Paper›PMID 28481132›Full record

ArticleInternational journal of toxicology

Disruption of Estrogen Receptor Alpha in Rats Results in Faster Initiation of Compensatory Regeneration Despite Higher Liver Injury After Carbon Tetrachloride Treatment.

Steven R McGreal, Karim Rumi, Michael J Soares, Benjamin L Woolbright, Hartmut Jaeschke, Udayan Apte

Open access · bronzeAbstract read
In one paragraph

Article in International journal of toxicology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Steven R McGreal1 Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.
Karim Rumi2 Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Michael J Soares2 Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, KS, USA.
Benjamin L Woolbright1 Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.
Hartmut Jaeschke1 Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.
Udayan Apte1 Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.
University of Kansas Medical Center · US

Funding

Nuclear Receptors in Liver Health and DiseaseP20GM103549 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI JAESCHKE, HARTMUT W. · 2012 to 2015
$8.1M
Pilot Grants ProgramP30GM118247 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI JAESCHKE, HARTMUT W. · 2016 to 2020
$5.5M
TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYT32ES007079 · NIEHS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI HAGENBUCH, BRUNO · 1985 to 2015
$4.1M
Mechanisms of Liver Regeneration After Acetaminophen-Induced Acute Liver FailureR01DK098414 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI APTE, UDAYAN · 2013 to 2023
$3.0M
Autophagy and Drug-Induced Liver InjuryR01DK102142 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI DING, WEN-XING, JAESCHKE, HARTMUT W. · 2014 to 2022
$2.7M
Rat Models for Sex Steroid ActionR21OD010478 · OD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SOARES, MICHAEL J · 2013 to 2014
$395k
NIDDK NIH HHS R01 DK098414NIDDK NIH HHS R01 DK102142NIEHS NIH HHS T32 ES007079NIGMS NIH HHS P20 GM103549NIGMS NIH HHS P30 GM118247NIH HHS R21 OD010478
6 · The paper itself

Abstract

Estrogen receptor alpha (ESR1) is 1 of the 2 intracellular receptors for estrogen and is expressed by hepatocytes in the liver. The role of ESR1 in the regulation of toxicant-induced liver injury and compensatory regeneration is not completely clear. We investigated the role of ESR1 in liver regeneration after carbon tetrachloride (CCl

Indexed as

Liver RegenerationAnimalsbeta CateninCarbon Tetrachloride PoisoningChemical and Drug Induced Liver InjuryEstrogen Receptor alphaFemaleLiverNF-kappa BRats, TransgenicWnt Signaling Pathwaybeta CateninEstrogen Receptor alphaNF-kappa BestrogennecrosisPCNAproliferationβ-catenin

Identifiers

PMID28481132
PMCPMC5535772
OpenAlexW2613915039

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.