Evidence map›Paper›PMID 28481111›Full record

ArticleBiochemistry2017

Conformational Changes in Active and Inactive States of Human PP2Cα Characterized by Hydrogen/Deuterium Exchange-Mass Spectrometry.

Sharlyn J Mazur, Elyssia S Gallagher, Subrata Debnath, Stewart R Durell, Kyle W Anderson, Lisa M Miller Jenkins, Ettore Appella, Jeffrey W Hudgens

Abstract read
In one paragraph

Article in Biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sharlyn J MazurLaboratory of Cell Biology, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 20892, United States.ORCID 0000-0002-6378-0791
Elyssia S GallagherBioprocess Measurement Group, Biomolecular Measurement Division, National Institute of Standards and Technology , Gaithersburg, Maryland 20899, United States.
Subrata DebnathLaboratory of Cell Biology, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 20892, United States.
Stewart R DurellLaboratory of Cell Biology, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 20892, United States.
Kyle W AndersonBioprocess Measurement Group, Biomolecular Measurement Division, National Institute of Standards and Technology , Gaithersburg, Maryland 20899, United States.
Lisa M Miller JenkinsLaboratory of Cell Biology, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 20892, United States.
Ettore AppellaLaboratory of Cell Biology, National Cancer Institute, National Institutes of Health , Bethesda, Maryland 20892, United States.
Jeffrey W HudgensBioprocess Measurement Group, Biomolecular Measurement Division, National Institute of Standards and Technology , Gaithersburg, Maryland 20899, United States.
National Institutes of Health · USNational Institute of Standards and Technology · US

Funding

CPTR - Mass Spectrometry UnitZICBC011430 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JENKINS, LISA · 2012 to 2025
$9.4M
Tumor Suppressor Protein, p53ZIABC005599 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI APPELLA, ETTORE · 2009 to 2025
$8.1M
TUMOR SUPPRESSOR PROTEIN, P53Z01BC005599 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI APPELLA, ETTORE · 1996 to 2008
$1.6M
Inhibitor Development Against the Wip1 PhosphataseZIABC011379 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI DURELL, STEWART · 2011 to 2022
$1.3M
Intramural NIH HHS Z01 BC005599Intramural NIST DOC 9999-NIST
6 · The paper itself

Abstract

PPM serine/threonine protein phosphatases function in signaling pathways and require millimolar concentrations of Mn

Indexed as

Deuterium Exchange MeasurementBinding SitesHumansMass SpectrometryProtein ConformationProtein Phosphatase 2CPPM1A protein, humanProtein Phosphatase 2C

Identifiers

PMID28481111
PMCPMC5593270
OpenAlexW2612198599

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.