Evidence map›Paper›PMID 28481062›Full record

ArticleBrain pathology (Zurich, Switzerland)2018

Preclinical transgenic and patient-derived xenograft models recapitulate the radiological features of human adamantinomatous craniopharyngioma.

Jessica K R Boult, John R Apps, Annett Hölsken, J Ciaran Hutchinson, Gabriela Carreno, Laura S Danielson, Laura M Smith, Tobias Bäuerle, Rolf Buslei, Michael Buchfelder and 7 more

Open access · hybridAbstract read
In one paragraph

Article in Brain pathology (Zurich, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Genomic drivers in craniopharyngiomas: Analysis of the AACR project GENIE database.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Article
  2. Article
  3. Pituitary Tumorigenesis-Implications for Management.Medicina (Kaunas, Lithuania) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Jessica K R BoultDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK.ORCID 0000-0002-3990-9663
John R AppsDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID 0000-0001-7902-482X
Annett HölskenDepartment of Neuropathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0002-0826-6300
J Ciaran HutchinsonHistopathology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Gabriela CarrenoDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Laura S DanielsonDivision of Clinical Sciences, The Institute of Cancer Research, London, UK.
Laura M SmithDivision of Clinical Sciences, The Institute of Cancer Research, London, UK.
Tobias BäuerleInstitute of Radiology, Preclinical Imaging Platform Erlangen (PIPE), University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Rolf BusleiDepartment of Neuropathology, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Michael BuchfelderDepartment of Neurosurgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
Alex K VirasamiHistopathology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Alexander KoersDivision of Clinical Sciences, The Institute of Cancer Research, London, UK.
Owen J ArthursHistopathology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Thomas S JacquesDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Louis CheslerDivision of Clinical Sciences, The Institute of Cancer Research, London, UK.
Juan Pedro Martinez-BarberaDevelopmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Simon P RobinsonDivision of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK.
Institute of Cancer Research · GBFriedrich-Alexander-Universität Erlangen-Nürnberg · DEGreat Ormond Street Hospital for Children NHS Foundation Trust · GBCRUK Lung Cancer Centre of Excellence · GB

Funding

Cancer Research UK 16464Cancer Research UK 18339Department of Health CDF-2017-10-037Department of Health NIHR-CS-012-002Medical Research Council MR/M000125/1
6 · The paper itself

Abstract

To assess the clinical relevance of transgenic and patient-derived xenograft models of adamantinomatous craniopharyngioma (ACP) using serial magnetic resonance imaging (MRI) and high resolution post-mortem microcomputed tomography (μ-CT), with correlation with histology and human ACP imaging. The growth patterns and radiological features of tumors arising in Hesx1

Indexed as

Disease Models, AnimalAnimalsbeta CateninCraniopharyngiomaHeterograftsHomeodomain ProteinsHumansMagnetic Resonance ImagingMaleMice, TransgenicMiddle AgedRepressor ProteinsX-Ray Microtomographybeta CateninCTNNB1 protein, mouseHesx1 protein, mouseHomeodomain ProteinsRepressor Proteinsadamantinomatous craniopharyngiomagenetically engineered mouse modelsmagnetic resonance imagingmicrocomputed tomographypatient-derived xenografts

Identifiers

PMID28481062
PMCPMC6099240
OpenAlexW2613099952

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.