ArticleHuman brain mapping2017
Cognitive and neuroimaging changes in healthy immigrants upon relocation to a high altitude: A panel study.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of long-term exposure to high altitude on brain structure in healthy people: an MRI-based systematic review and meta-analysis.Frontiers in psychiatry · 2023Pooled it
- Hyperbaric oxygen intervention enhances cooperative gains in high-trust people at high altitude: the role of medial prefrontal interbrain synchrony.Social cognitive and affective neuroscience · 2026Trial
- Dynamic functional connectivity variability may explain hypoxia-induced cognitive impairment at high-altitude.iScience · 2026Article
- Review
- Chronic high-altitude exposure and cognitive health in Chinese college students: a 4-year longitudinal neuroimaging study.Scientific reports · 2026Article
- Neurodevelopmental outcomes of infants born at high altitude: evidence from Tibet.Pediatric research · 2026Article
- Relationship between spontaneous EEG oscillations at 7 and 45 days of acute plateau exposure and the plateau acclimatization index.Frontiers in neuroscience · 2026Article
- Alterations in static and dynamic topological properties of brain functional network after chronic high altitude exposure: a panel study.Frontiers in aging neuroscience · 2026Article
- Neural-behavioral dissociation under acute high-altitude stress: an exploratory ERP study of non-specific neural recruitment and rTMS effects.Frontiers in behavioral neuroscience · 2026Article
- Nocturnal hypoxia moderates the relationship between rapid eye movement sleep and anxiety.BMC psychiatry · 2025Article
- Hypoxia's Impact on Hippocampal Functional Connectivity: Insights from Resting-State fMRI Studies.Brain sciences · 2025Review
- Gut microbiota's role in high-altitude cognitive impairment: the therapeutic potential of Clostridium sp. supplementation.Science China. Life sciences · 2025Article
- Smoking and High-Altitude Exposure Affect Intrinsic Neural Activity: A fMRI Study of Interactive Effects.Addiction biology · 2025Article
- Tetramethylpyrazine exerts neuroprotective effects in a mouse model of acute hypobaric hypoxia.Frontiers in pharmacology · 2025Article
- Multiparameter resting-state functional magnetic resonance imaging as an indicator of neuropsychological changes in Binswanger's disease with mild cognitive impairment.Frontiers in aging neuroscience · 2025Article
- Neurological Biomarker Profiles in Royal Canadian Air Force (RCAF) Pilots and Aircrew.Brain sciences · 2024Article
- [Movable Array of Magnetoencephalography With Optically Pumped Magnetometers Effectively Captures Primary Auditory-Evoked Response Signals in Healthy Populations at Low Altitudes].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- Dynamic brain functional states associated with inhibition control under different altitudes.Cognitive neurodynamics · 2024Article
- EEG and fNIRS datasets based on Stroop task during two weeks of high-altitude exposure in new immigrants.Scientific data · 2024Article
- Intermittent hypoxia training effectively protects against cognitive decline caused by acute hypoxia exposure.Pflugers Archiv : European journal of physiology · 2024Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive and neuroimaging changes under chronic high-altitude exposure have never been followed up and dynamically assessed.
objectivesTo investigate the cognitive and brain structural/functional alterations associated with chronic high-altitude exposure.
methodsSixty-nine college freshmen that were immigrating to Tibet were enrolled and followed up for two years. Neuropsychological tests, including verbal/visual memory and simple/recognition reaction time, were utilized to determine whether the subjects' cognitive function had changed in response to chronic high-altitude exposure. Structural magnetic resonance imaging (MRI) and resting-state functional MRI (rs-fMRI) were used to quantify brain gray matter (GM) volumes, regional homogeneity (ReHo) and functional connectivity (FC) alterations before and after exposure. Areas with changes in both GM and ReHo were used as seeds in the inter-regional FC analysis.
resultsThe subjects showed significantly lower accuracy in memory tests and longer reaction times after exposure, and neuroimaging analysis showed markedly decreased GM volumes and ReHo in the left putamen. FC analysis seeding of the left putamen showed significantly weakened FC with the superior temporal gyrus, anterior/middle cingulate gyrus and other brain regions. In addition, decreased ReHo was found in the superior temporal gyrus, superior parietal lobule, anterior cingulate gyrus and medial frontal gyrus, while increased ReHo was found in the hippocampus. Differences in ReHo/FC before and after high-altitude exposure in multiple regions were significantly correlated with the cognitive changes.
conclusionCognitive functions such as working memory and psychomotor function are impaired during chronic high-altitude exposure. The putamen may play an important role in chronic hypoxia-induced cognitive impairment. Hum Brain Mapp 38:3865-3877, 2017. © 2017 Wiley Periodicals, Inc.
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